تأثیر دو شیوۀ تمرین هوازی (تداومی و تناوبی) و مکمل‌یاری با کمپلکس وانادیم- روی بر بیان ژن‌های آنتی‌اکسیدانی در بافت بیضۀ رت‌های تغذیه‌شده با محلول فروکتوز

[1] Ter Horst KW, Schene MR, Holman R, Romijn JA, Serlie MJ. Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials. The American journal of clinical nutrition. 2016 Dec 1;104(6):1562-76. https://doi.org/10.3945/ajcn.116.137786

[2] Taskinen MR, Packard CJ, Borén J. Dietary fructose and the metabolic syndrome. Nutrients. 2019 Aug 22;11(9):1987. https://doi.org/10.3390/nu11091987.

[3] Cioffi F, Senese R, Lasala P, Ziello A, Mazzoli A, Crescenzo R, Liverini G, Lanni A, Goglia F, Iossa S. Fructose-rich diet affects mitochondrial DNA damage and repair in rats. Nutrients. 2017 Mar 24;9(4):323. https://doi.org/10.3390/nu9040323.

[4] Baena M, Sangüesa G, Dávalos A, Latasa MJ, Sala-Vila A, Sánchez RM, Roglans N, Laguna JC, Alegret M. Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues. Scientific reports. 2016 May 19;6(1):26149. https://doi.org/10.1038/srep26149.

[5] Medaglia DS, Vieira HR, da Silva Silveira S, Siervo GE, da Silva Marcon MS, de Freitas Mathias PC, Fernandes GS. High-fructose diet during puberty alters the sperm parameters, testosterone concentration, and histopathology of testes and epididymis in adult Wistar rats. Journal of Developmental Origins of Health and Disease. 2022 Feb;13(1):20-7. https://doi.org/10.1017/S2040174420001385..

[6] Romic S, Djordjevic A, Tepavcevic S, Culafic T, Stojiljkovic M, Bursac B, Stanisic J, Kostic M, Gligorovska L, Koricanac G. Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats. Food & function. 2020; 11(2):1455-66. https://doi.org/10.1039/C9FO02306B.

[7] Sadowska J, Rygielska M. The effect of high fructose corn syrup on the plasma insulin and leptin concentration, body weight gain and fat accumulation in rat. Advances in Clinical and Experimental Medicine. 2019; 28(7):879-84.https://doi: 10.17219/acem/94069.

[8] Hsia SM, Chiang YF, Chen HY, Ali M, Wang PS, Wang KL. Effect of High-Fructose Diet-Induced Metabolic Syndrome on the Pituitary-Gonadal Axis in Male Rats. Biomedicines. 2022 Nov 23; 10(12):3009. https://doi.org/10.3390/biomedicines10123009.

[9] Jarukamjorn K, Jearapong N, Pimson C, Chatuphonprasert W. A high-fat, high-fructose diet induces antioxidant imbalance and increases the risk and progression of nonalcoholic fatty liver disease in mice. Scientifica. 2016 Jan 1;2016. https://doi.org/10.1155/2016/5029414.

[10] Rato L, Alves MG, Socorro S, Carvalho RA, Cavaco JE, Oliveira PF. Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro. Bioscience Reports. 2012 Feb 1;32(1):61-9, https://doi.org/10.1042/BSR20110030.

[11] Alves MG, Martins AD, Rato L, Moreira PI, Socorro S, Oliveira PF. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2013May1;1832(5):62635,https://doi.org/10.1016/j.bbadis.2013.01.011.

[12] Rato L, Alves MG, Dias TR, Lopes G, Cavaco JE, Socorro S, Oliveira PF. High-energy diets may induce a pre-diabetic state altering testicular glycolytic metabolic profile and male reproductive parameters. Andrology. 2013 May;1(3):495-504, https://doi.org/10.1111/j.2047-2927.2013.00071.x

[13] Condorelli RA, Vicari E, Calogero AE, La Vignera S. Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy. Asian Journal of Andrology. 2014 Sep;16(5):761, https://doi.org/10.4103/1008-682X.125911.

[14] Oliveira PF, Martins AD, Moreira AC, Cheng CY, Alves MG. The Warburg effect revisited—lesson from the Sertoli cell. Medicinal research reviews. 2015 Jan;35(1):126-51, https://doi.org/10.1002/med.21325.

[15] Mann T, Lutwak-Mann C. Enzymes as biochemical markers in differentiating germ cells. Male reproductive function and semen: themes and trends in physiology, biochemistry and investigative andrology. Springer-Verlag, Berlin, Heidelberg, New York. 1981:101-6, https://catalogue.nla.gov.au/Record/1443335

[16] Rato L, Alves MG, Dias TR, Cavaco JE, Oliveira PF. Testicular metabolic reprogramming in neonatal streptozotocin-induced type 2 diabetic rats impairs glycolytic flux and promotes glycogen synthesis. Journal of Diabetes Research. 2015 May 12;2015, https://doi.org/10.1155/2015/973142

[17] Leiderman B, Mancini RE. Glycogen content in the rat testis from postnatal to adult ages. Endocrinology. 1969 Sep 1;85(3):607-9, https://doi.org/10.1210/endo-85-3-607.

[18] Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, Tarnopolsky MA, Gibala MJ. Intermittent and continuous high‐intensity exercise training induce similar acute but different chronic muscle adaptations. Experimental physiology. 2014 May 1; 99(5):782-91. https://doi.org/10.1113/expphysiol.2013.077453.

[19] Omidifar A, Shirvani H, Taheri RA, Gorgani-Firouzjae S, Delfan M, Kalaki-Jouybari F, Khakdan S. Protective effects of HIIT vs. CET exercise training on high-fat-high-fructose diet-induced hyperglycemia, hyperlipidemia, and histopathology of liver in rats: regulation of SIRT1/PGC-1α. Sport Sciences for Health. 2021 Sep; 17:707-15. https://doi.org/10.1007/s11332-021-00736-9.[In Persian]

[20] Groussard C, Maillard F, Vazeille E, Barnich N, Sirvent P, Otero YF, Combaret L, Madeuf E, Sourdrille A, Delcros G, Etienne M. Tissue-specific oxidative stress modulation by exercise: A comparison between MICT and HIIT in an obese rat model. Oxidative medicine and cellular longevity. 2019 Jul 14;2019. https://doi.org/10.1155/2019/1965364.

[21] Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports medicine. 2015 May; 45:679-92. https://doi.org/10.1007/s40279-015-0321-z.

[22] Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life sciences. 2017 Dec 15; 191:122-31. https://doi.org/10.1016/j.lfs.2017.08.023.

[23] Hood MS, Little JP, Tarnopolsky MA, Myslik F, Gibala MJ. Low-volume interval training improves muscle oxidative capacity in sedentary adults. Medicine and science in sports and exercise. 2011 Oct 1; 43(10):1849-56. https://doi.org/10.1249/mss.0b013e3182199834.

[24] Noorishorabi Y, Talebi-Garakani E, Safarzade A, Rocha-Rodrigues S, Kolahdouzi S. Continuous and intermittent exercise training responses in liver and white adipose tissue aquaglyceroporins. Human Movement. 2022; 23(1):105-12.[In Persian]

[25] Little JP, Safdar A, Wilkin GP, Tarnopolsky MA, Gibala MJ. A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms. The Journal of physiology. 2010 Mar 15; 588(6):1011-22. https://doi.org/10.1113/jphysiol.2009.181743.

[26] Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life sciences. 2017 Dec 15; 191:122-31. https://doi.org/10.1016/j.lfs.2017.08.023.

[27] Bahmani M, Peeri M, Azarbayjani M, Delfan M. The effect of the aerobic continues versus high-intensity interval training on IRE1 expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus. Razi Journal of Medical Sciences. 2020 Jan 1; 26(12):67-77.[In Persian]

[28] Khalafi M, Mohebbi H, Karimi P, Faridnia M, Tabari E. The effect of high intensity interval training and moderate intensity continuous training on mitochondrial content and pgc-1α of subcutaneous adipose tissue in male rats with high fat diet induced obesity. Journal of Sport Biosciences. 2018 Nov 22; 10(3):297-315. https://doi.org/10.22059/jsb.2018.258026.1273.[In Persian]

[29] De Nardi AT, Tolves T, Lenzi TL, Signori LU, da Silva AM. High-intensity interval training versus continuous training on physiological and metabolic variables in pre-diabetes and type 2 diabetes: a meta-analysis. Diabetes research and clinical practice. 2018 Mar 1; 137:149-59. https://doi.org/10.1016/j.diabres.2017.12.017.

[30] Wewege M, Van Den Berg R, Ward RE, Keech A. The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews. 2017 Jun; 18(6):635-46. https://doi.org/10.1111/obr.12532.

[31] Daryanoosh F, Mehboodi M, Mortazavi M, Motesharee E. The Effect of 8 weeks of Intense Aerobic Exercise on Plasma Levels of Obestatin, Leptin, Insulin and Growth Hormones in Male Obese Sprague‌ Dawley Rats. Journal of Arak University of Medical Sciences. 2014 Dec 10; 17(9):37-45. [In Persian]

[32] Gibala MJ. Physiological adaptations to low-volume high-intensity interval training. Sports Science Exchange. 2015; 28(139):1-6.

[33] Karaman ME, Tektemur A. The therapeutic effects of distinct exercise types on metabolic syndrome‐induced reproductive system impairment in male rats: potential contribution of mitochondria‐related genes. Andrologia. 2022 May;54(4):e14391. https://doi.org/10.1111/and.14391

[34] Gu K, Xiang W, Zhang Y, Sun K, Jiang X. The association between serum zinc level and overweight/obesity: a meta-analysis. European journal of nutrition. 2019 Dec; 58:2971-82. https://doi.org/10.1007/s00394-018-1876-x.

[35] Rodríguez-Pérez C, Gómez-Peña C, Pérez-Carrascosa FM, Vrhovnik P, Echeverría R, Salcedo-Bellido I, Mustieles V, Željka F, Arrebola JP. Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort. Environmental pollution. 2021 Oct 1; 286:117496. https://doi.org/10.1016/j.envpol.2021.117496.

[36] Azam A, Raza MA, Sumrra SH. Therapeutic application of zinc and vanadium complexes against diabetes mellitus a coronary disease: A review. Open Chemistry. 2018 Jan 1; 16(1):1153-65. https://doi.org/10.1515/chem-2018-0118.[In Persian]

[37] Pirmoradi L, Noorafshan A, Safaee A, Dehghani GA. Quantitative assessment of proliferative effects of oral vanadium on pancreatic islet volumes and beta cell numbers of diabetic rats. Iranian Biomedical Journal. 2016 Jan;20(1):18. https://doi: 10.7508/ibj.2016.01.003.[In Persian]

[38] Martins MD, Oliveira AS, de Carvalho VB, Rodrigues LA, Arcanjo DD, Dos Santos MA, Machado JS, de Moura Rocha M. Effects of zinc supplementation on glycemic control and oxidative stress in experimental diabetes: A systematic review. Clinical Nutrition ESPEN. 2022 Oct 1;51:28-36. https://doi.org/10.1016/j.clnesp.2022.08.003

[39] Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. The Journal of clinical investigation. 1995 Jun 1;95(6):2501-9. https://doi: 10.1172/JCI117951.

[40] Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. Metabolic effects of sodium meta-vanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. The Journal of Clinical Endocrinology & Metabolism. 1995 Nov 1; 80(11):3311-20. https://doi.org/10.1210/jcem.80.11.7593444.

[41] Kurt O, Ozden TY, Ozsoy N, Tunali S, Can A, Akev N, Yanardag R. Influence of vanadium supplementation on oxidative stress factors in the muscle of STZ-diabetic rats. Biometals. 2011 Oct;24:943-9. https://doi.org/10.1007/s10534-011-9452-3 

[42] Kolahdouzi S, Talebi-Garakani E, Hamidian G, Safarzade A. Exercise training prevents high-fat diet-induced adipose tissue remodeling by promoting capillary density and macrophage polarization. Life sciences. 2019 Mar 1; 220:32-43. https://doi.org/10.1016/j.lfs.2019.01.037.[In Persian]

[43] Moreira JB, Bechara LR, Bozi LH, Jannig PR, Monteiro AW, Dourado PM, Wisløff U, Brum PC. High-versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats. Journal of applied physiology. 2013 Apr 15;114(8):1029-41. https://doi.org/10.1152/japplphysiol.00760.2012

[44] Linden MA, Fletcher JA, Morris EM, Meers GM, Laughlin MH, Booth FW, Sowers JR, Ibdah JA, Thyfault JP, Rector RS. Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training. Medicine and science in sports and exercise. 2015 Mar;47(3):556. https://doi.org/10.1249/mss.0000000000000430

[45] Kolahian S, Sadri H, Larijani A, Hamidian G, Davasaz A. Supplementation of diabetic rats with leucine, zinc, and chromium: effects on function and histological structure of testes. Int J Vitam Nutr Res. 2015 Dec 1;85:311-21. https://doi.org/10.1024/0300-9831/a000244.[In Persian]

[46] Sakurai H, Kojima Y, Yoshikawa Y, Kawabe K, Yasui H. Antidiabetic vanadium (IV) and zinc (II) complexes. Coordination Chemistry Reviews. 2002 Mar 1; 226(1-2):187-98. https://doi.org/10.1016/S0010-8545(01)00447-7.

[47] Toop CR, Gentili S. Fructose beverage consumption induces a metabolic syndrome phenotype in the rat: a systematic review and meta-analysis. Nutrients. 2016 Sep 20;8(9):577. https://doi.org/10.3390/nu8090577.

[48]Nouchi Y, Munetsuna E, Yamada H, Yamazaki M, Ando Y, Mizuno G, Fujii R, Kageyama I, Wakasugi T, Sakakibara T, Teshigawara A. Effects of High-Fructose Corn Syrup Intake on Glucocorticoid Metabolism in Rats During Childhood, Adolescence and Adulthood. Experimental and Clinical Endocrinology & Diabetes. 2022 Dec;130(12):814-20. https://doi.org/10.1055/a-1936-3310.

[49]Stricker S, Rudloff S, Geier A, Steveling A, Roeb E, Zimmer KP. Fructose consumption—free sugars and their health effects. Deutsches Ärzteblatt International. 2021 Feb;118(5):71. https://doi.org/10.3238/arztebl.m2021.0010.

[50] Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports medicine. 2015 May;45:679-92. https://doi.org/10.1007/s40279-015-0321-z.

[51] Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life sciences. 2017 Dec 15;191:122-31. https://doi.org/10.1016/j.lfs.2017.08.023

[52] Ram A, Marcos L, Jones MD, Morey R, Hakansson S, Clark T, Ristov M, Franklin A, McCarthy C, De Carli L, Ward R. The effect of high-intensity interval training and moderate-intensity continuous training on aerobic fitness and body composition in males with overweight or obesity: A randomized trial. Obesity Medicine. 2020 Mar 1;17:100187. https://doi.org/10.3390/ijerph20064741

[53] Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D’alessio D, Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. The Journal of Clinical Endocrinology & Metabolism. 2004 Jun 1;89(6):2963-72, https://doi.org/10.1210/jc.2003-031855.

[54] Ferder L, Ferder MD, Inserra F. The role of high-fructose corn syrup in metabolic syndrome and hypertension. Current hypertension reports, https://doi.org/10.1007/s11906-010-0097-3.

[55] Andlib N, Sajad M, Kumar R, Thakur SC. Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: A mechanistic insight. Acta Histochemica. 2023 Jan 1;125(1):151974.[In Persian]

[56] Ghadery B, Ghazalian F, Hosseini SA, Natanzy HA, Shamsoddini A. The Effect of Six Weeks of High Intensity Interval Training on eNOS and PGC-1α Gene Expression in the Heart Tissue of Male Obese Rats. Jundishapur Journal of Health Sciences. 2020 Apr 30;12(2). https://doi.org/10.5812/jjhs.100280.[In Persian]

[57] Noraie F, Peeri M, Azarbayjani MA, Delfan M. The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats. Medical Journal of Tabriz University of Medical Sciences. 2021 Apr 17;43(1):100-7. https://doi.org/10.34172/mj.2021.034.[In Persian]

[58] Liu Y, Dong G, Zhao X, Huang Z, Li P, Zhang H. Post-exercise effects and long-term training adaptations of hormone sensitive lipase lipolysis induced by high-intensity interval training in adipose tissue of mice. Frontiers in Physiology. 2020 Nov 25;11:535722. https://doi.org/10.3389/fphys.2020.535722.

[59] Simon D, Preziosi P, Barrett-Connor E, Roger M, Saint-Paul M, Nahoul K, et al.. Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study. Diabetologia (1992) 35:173–7. https://doi.org/10.1007/BF00402551.

[60] Pitteloud N, Hardin M, Dwyer AA, Valassis E, Yialamas M, Elahi D, et al.. Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab. (2005) 90:2636–41. https://doi.org/10.1210/jc.2004-2190.

[61] Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, et al.. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care (2005) 28:1636–42. https://doi.org/10.2337/diacare.28.7.1636.

[62] Kasturi SS, Tannir J, Brannigan RE. The metabolic syndrome and male infertility. J Androl 2008;29:251–259. https://doi.org/10.2164/jandrol.107.003731.

[63] Pengam M, Moisan C, Simon B, Guernec A, Inizan M, Amérand A. Training protocols differently affect AMPK–PGC-1α signaling pathway and redox state in trout muscle. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2020 May 1;243:110673. https://doi.org/10.1016/j.cbpa.2020.110673.

[64] Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. The journal of physiological sciences. 2018 Jan;68(1):19-31. https://doi.org/10.1007/s12576-017-0571-7.

[65] Adachi Y, Sakurai H. Insulin-mimetic vanadyl (IV) complexes as evaluated by both glucose-uptake and inhibition of free fatty acids (FFA)-release in isolated rat adipocytes. Chemical and pharmaceutical bulletin. 2004;52(4):428-33. https://doi.org/10.1248/cpb.52.428.

[66] Semiz S. Vanadium as potential therapeutic agent for COVID-19: A focus on its antiviral, antiinflamatory, and antihyperglycemic effects. Journal of Trace Elements in Medicine and Biology. 2022 Jan 1;69:126887. https://doi.org/10.1016/j.jtemb.2021.126887.

[67] Vardatsikos G, Mehdi MZ, Srivastava AK. Bis (maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes toits glucoregulatory responses. International Journal of Molecular Medicine. 2009 Sep 1;24(3):303-9. https://doi.org/10.3892/ijmm_00000233.

[68] Gallardo-Vera F, Diaz D, Tapia-Rodriguez M, Fortoul van der Goes T, Masso F, Rendon-Huerta E, Montaño LF. Vanadium pentoxide prevents NK-92MI cell proliferation and IFN γ secretion through sustained JAK3 phosphorylation. Journal of immunotoxicology. 2016 Jan 2;13(1):27-37. https://doi.org/10.3109/1547691X.2014.996681.

[69] Alshammari E, Shafi S, Nurmi-Lawton J, Taylor A, Lanham-New S, Ferns G. Altered antioxidant and trace-element status in adolescent female gymnasts. International journal of sport nutrition and exercise metabolism. 2010 Aug 1;20(4):291-8. https://doi.org/10.1123/ijsnem.20.4.291

[70] Koury JC, Portella ES, de Oliveira CF, Lopes GC, Donangelo CM. Zinc and Copper Biochemical lndices of Antioxidant Status in Elite Athletes of Different Modalities. International Journal of Sport Nutrition & Exercise Metabolism. 2004 Jun 1;14(3). https://doi.org/10.1123/ijsnem.14.3.358.