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Fazeli, Z., Rajabibazl, M., Salami, S., Vazifeh Shiran, N., Ghaderian, SMH., Omrani, MD.. (1395). Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells. , 27(2), 105-112.
Z. Fazeli; M. Rajabibazl; S. Salami; N. Vazifeh Shiran; SMH. Ghaderian; MD. Omrani. "Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells". , 27, 2, 1395, 105-112.
Fazeli, Z., Rajabibazl, M., Salami, S., Vazifeh Shiran, N., Ghaderian, SMH., Omrani, MD.. (1395). 'Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells', , 27(2), pp. 105-112.
Fazeli, Z., Rajabibazl, M., Salami, S., Vazifeh Shiran, N., Ghaderian, SMH., Omrani, MD.. Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells. , 1395; 27(2): 105-112.

Gene Expression Profile of Adherent Cells Derived From Human Peripheral Blood: Evidence of Mesenchymal Stem Cells

Journal of Sciences, Islamic Republic of Iran
مقاله 1، دوره 27، شماره 2، تیر 2016، صفحه 105-112    اصل مقاله (2.04 M)
نوع مقاله: Final File
نویسندگان
Z. Fazeli1؛ M. Rajabibazl2؛ S. Salami2؛ N. Vazifeh Shiran3؛ SMH. Ghaderian* 4؛ MD. Omrani* 4
11 Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
22 Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
33 Department of Hematology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
44 Urogenital stem cell research center, Shahid Beheshti University of medical sciences, Tehran, Islamic Republic of Iran
چکیده
Mesenchymal stem cells (MSCs) provide a novel option in cellular therapy and tissue engineering. Recent studies indicated that it is possible to obtain MSCs from peripheral blood by attachment ability to plastic surface. To evaluate adherent cells derived from peripheral blood, their expression profile and surface markers were investigated. The results of RT-PCR indicated that these cells expressed MECP2, SLITRK2, SLITRK4 as well as the neuronal markers Nestin, β III tubulin, NFM, MAP2 and NSE. In the present study, a panel of surface markers were analysed by flow cytometry. These cells display a fibroblast like morphology as well as known sources of MSCs. The results obtained from immune-staining represented that these cells were negative for CD14, CD45, CD15 and CD24, whereas they were positive for CD29, CD44, CD105, CD73, CD166 and CD184. Our data indicated that the peripheral blood could be considered as a source of MSCs with high yield.
کلیدواژه‌ها
Mesenchymal stem cells؛ Neuronal markers؛ Expression profile؛ Immune-phenotyping
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