پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 163 |
| تعداد شماره‌ها | 6,711 |
| تعداد مقالات | 72,495 |
| تعداد مشاهده مقاله | 130,294,884 |
| تعداد دریافت فایل اصل مقاله | 102,767,054 |
In Vivo Antitrypanosomal Activities of Methanolic Extract of Lawsonia inermis Linn. Leaves on Trypanosome Brucei Infected Wistar rat | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 دی 1403 اصل مقاله (1004.56 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.376800.1005578 | ||
| نویسندگان | ||
| Abdulfatai Aremu* 1؛ Saliu Akanni Ameen2؛ Ganiu Jimoh Akorede1؛ Aishat Omobolanle Olatunji2؛ Afisu Basiru3؛ Akeem Olayiwola Ahmed4؛ Rafiu Adebisi Kadir2 | ||
| 1Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria. | ||
| 2Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria. | ||
| 3Department of Veterinary Physiology and Biochemistry Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.. | ||
| 4Department of Veterinary Microbiology Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria. | ||
| چکیده | ||
| Background: Trypanosomiasis is a major problem affecting both human and animals. Nearly 30,000 personalities in various nations of Sub-Saharan Africa have African trypanosomiasis. It has led to about 21,000 deaths yearly. Objectives: This experiment was conducted to evaluate the anti-trypanocidal effects of Lawsonia inermis in rats infected with T. brucei. Methods: 30 rats were allotted to groups (1-5) of six rats each. Group 1 (negative control), 2 (tryps control), 3 (Diminazene (DA) 7 mg/kg), 4 (Lawsonia inermis (LI) at 200 mg/kg), and 5 (DA+LI). All rats in groups (2-5) were infected with 3x106 of Trypanosoma brucei per ml of blood. Result: Percentage weight gain of rats in diminazene extract showed increased weight gain (6.3%) when compared to tryps-control. Diminazene showed significant weight gain when compared with the negative control. The survivability rate showed that DA, LI and DA+LI combination survived for 14 days without visible relapse. The PVC, RBC, WBC, platelets and MCV increased significantly in the extract treated groups while MCH and MCHC decreased significantly. Lymphocytes, Monocytes, Eosinophils and Basophils increased significantly compared to the control. Globulin, AST, ALT, ALP and Blood urea nitrogen increased non-significantly. Creatinine and Total bilirubin significantly decreased compared to untreated control. Lawsonia inermis significantly increased GSH, GST, GPx, SOD, while decreasing MDA and inflammatory cytokines (IL-1, 6, and 12) when compared to untreated control groups. Conclusions: Lawsonia inermis reduced the level of parasitemia in a transient phase and drug-extract combination cleared the parasitemia within shortest time | ||
| کلیدواژه‌ها | ||
| Extract؛ Lawsonia inermis؛ T. brucei؛ trypanocidal drug؛ Wistar rats | ||
|
آمار تعداد مشاهده مقاله: 64 تعداد دریافت فایل اصل مقاله: 76 |
||
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب