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Short-term vs. Long-term Effects of Topical administration of latanoprost on Schirmer Tear Test, Intraocular Pressure, and Pupil Size in Clinically Normal Dogs | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 مهر 1403 اصل مقاله (540.59 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.375438.1005557 | ||
| نویسندگان | ||
| Armin Shokoohimand1؛ Farnoosh Arfaee* 1؛ Ahmad Asghari2؛ Ehsan Khaksar3 | ||
| 1Department of Clinical Science, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. | ||
| 2Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran. | ||
| 3Department of Clinical Science, Faculty of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran. | ||
| چکیده | ||
Background: Glaucoma poses significant challenges in veterinary medicine, necessitating effective management strategies to mitigate vision loss. Prostaglandin analogs like latanoprost offer promising avenues due to their ability to lower intraocular pressure (IOP). However, a comprehensive understanding of latanoprost's short-term and long-term effects on ocular parameters in dogs remains limited. Objectives: This study aims to compare the effects of short-acting versus long-acting latanoprost on the Schirmer Tear Test (STT), intraocular pressure (IOP), and pupil size in clinically normal dogs, highlighting its potential applications in veterinary ophthalmology. By examining both short-term and long-term impacts, this study offers novel insights into the temporal pharmacological effects of latanoprost. Methods: Twenty healthy adult male cross-bred dogs underwent thorough baseline assessments before receiving either latanoprost or saline drops in randomly chosen eyes over a three-week period. STT, IOP, and pupil size were measured at various intervals using standardized protocols. Statistical analysis was conducted to compare treated and untreated eyes. Results: Short-term analysis revealed significant IOP reduction at 6 and 8 hours post-latanoprost instillation, with no significant changes in STT values. Pupil diameter showed significant differences between treated and untreated eyes. Long-term effects included sustained IOP reduction and pupil constriction after three weeks of latanoprost treatment. Conclusions: Latanoprost demonstrates rapid and sustained efficacy in reducing IOP in dogs, with potential implications for glaucoma management. While it does not significantly affect tear production, it modulates pupil size, highlighting its multifaceted pharmacological effects. The study affirms latanoprost's safety profile and underscores its therapeutic potential in veterinary ophthalmology, urging further exploration into its mechanisms and applications. | ||
| کلیدواژه‌ها | ||
| Dogs؛ latanoprost؛ Glaucoma؛ intraocular pressure؛ Schirmer Tear Test | ||
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