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Nano-curcumin Attenuates Brain Oxidative Stress and Cognitive Deficit in Ketamine-induced Anesthesia in Adolescent Rats | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 14 مهر 1403 اصل مقاله (1.32 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.374096.1005545 | ||
| نویسندگان | ||
| Reza Tahmaseby1؛ Abbas Raisi* 2؛ Majid Taati3؛ Soroush Afshar Ghahremani4 | ||
| 1Graduated from the Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran | ||
| 2Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. | ||
| 3Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. | ||
| 4Department of Health and Food Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. | ||
| چکیده | ||
| Background: Anesthetics play a crucial role in medical procedures, but some may pose neurotoxic effects, particularly through oxidative stress mechanisms. Ketamine, a widely used anesthetic, has been linked to neurotoxicity characterized by an imbalance in reactive oxygen species (ROS) production and antioxidant defenses. Objective: This study aimed to investigate the effects of nano-curcumin on ketamine-induced alterations in hippocampal antioxidant components and cognitive functions in adolescent rats. Methods: In two experiments, sixty male Wistar rats were used. Experiment 1 assessed the biochemical effects of nano-curcumin on ketamine anesthesia, while Experiment 2 evaluated its impact on spatial learning and memory. At the end of experiments oxidative stress parameters such as MDA, SOD, GPx, and CAT were measured. Moreover, Morris water maze test was performed to assess cognitive function. Result: Biochemical assays revealed that ketamine anesthesia reduced antioxidant enzyme activity and total antioxidant capacity in the hippocampus, while increasing lipid peroxidation. Nano-curcumin treatment alleviated these effects, restoring antioxidant enzyme activity by significantly increasing SOD and CAT levels and reducing lipid peroxidation (P≤0.05). In the Morris water maze test, ketamine anesthesia impaired spatial learning and memory, which was attenuated by nano-curcumin pretreatment. Conclusions: In conclusion, nano-curcumin effectively prevented ketamine-induced neurotoxicity by restoring antioxidant balance and ameliorating cognitive deficits. These findings highlight the potential therapeutic utility of nano-curcumin in mitigating anesthesia-induced neurotoxicity and emphasize the importance of oxidative stress in anesthesia-related neurological complications. | ||
| کلیدواژه‌ها | ||
| Anesthesia؛ Brain؛ Ketamine؛ Nano-curcumin؛ Oxidative stress | ||
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آمار تعداد مشاهده مقاله: 37 تعداد دریافت فایل اصل مقاله: 97 |
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