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Arab, Hossein Ali, Karami, Maryam, Jamshidian, Javad, Kheirollahi, Asma. (1403). The Effect of Simultaneous Use of Opium and Ischemic Preconditioning on Ischemia/Reperfusion Injury in the Rat Liver. , (), -. doi: 10.22059/ijvm.2024.375715.1005566
Hossein Ali Arab; Maryam Karami; Javad Jamshidian; Asma Kheirollahi. "The Effect of Simultaneous Use of Opium and Ischemic Preconditioning on Ischemia/Reperfusion Injury in the Rat Liver". , , , 1403, -. doi: 10.22059/ijvm.2024.375715.1005566
Arab, Hossein Ali, Karami, Maryam, Jamshidian, Javad, Kheirollahi, Asma. (1403). 'The Effect of Simultaneous Use of Opium and Ischemic Preconditioning on Ischemia/Reperfusion Injury in the Rat Liver', , (), pp. -. doi: 10.22059/ijvm.2024.375715.1005566
Arab, Hossein Ali, Karami, Maryam, Jamshidian, Javad, Kheirollahi, Asma. The Effect of Simultaneous Use of Opium and Ischemic Preconditioning on Ischemia/Reperfusion Injury in the Rat Liver. , 1403; (): -. doi: 10.22059/ijvm.2024.375715.1005566

The Effect of Simultaneous Use of Opium and Ischemic Preconditioning on Ischemia/Reperfusion Injury in the Rat Liver

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 تیر 1403    اصل مقاله (608.25 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2024.375715.1005566
نویسندگان
Hossein Ali Arab* 1؛ Maryam Karami2؛ Javad Jamshidian3؛ Asma Kheirollahi2
1Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Irann
2Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
چکیده
BACKGROUND: Ischemia preconditioning (IPC) is known as a protective procedure against the injury induced by ischemia/reperfusion (IR) injury. There is also evidence that the administration of opioids may have the same effects on the injury.
OBJECTIVES: The aim of this study was to investigate the ameliorative effects of simultaneous use of opium and IPC on lobar IR injury in the rat liver.
METHODS: Twenty-five adult male rats were randomly divided into 5 groups: 1) sham-operated, 2) IR, 3) IR+IPC, 4) opium+IPC+IR, and 5) naloxone+opium+IPC+IR. At the end of the reperfusion, blood and tissue samples were obtained to assay alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the blood as well as determining oxidative stress by measuring malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) activities in the liver tissues.
RESULTS: The levels of ALT, AST and MDA were significantly increased in the IR group compared to the sham-operated group (P<0.05). However, the application of IPC and IPC+opium significantly decreased the release of these enzymes, while the simultaneous application of opium and IPC had a stronger restorative effect on the IR injury (P<0.05). The recovery effects induced by opium+IPC in terms of TAC, SOD and catalase were also higher than that of the IPC alone. However, the use of naloxone significantly inhibited the protective effects induced by the opium.
CONCLUSIONS: It can be concluded that the simultaneous use of opium and IPC is able to accelerate the protective effects of IPC on the IR injury.
کلیدواژه‌ها
Ischemia preconditioning؛ Ischemia/reperfusion؛ Liver؛ Opium؛ Rat
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