پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 158 |
| تعداد شماره‌ها | 6,244 |
| تعداد مقالات | 67,922 |
| تعداد مشاهده مقاله | 115,664,208 |
| تعداد دریافت فایل اصل مقاله | 90,429,568 |
Role of TNF-α in Experimental Streptococcus pneumoniae Infection in Lambs | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 اردیبهشت 1403 اصل مقاله (1.83 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.373187.1005527 | ||
| نویسندگان | ||
| Abbas Abedulyemah Hamza* ؛ Zainab Ismail Ibrahim | ||
| Department of Pathology and Poultry Diseases,College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq | ||
| چکیده | ||
| BACKGROUND Streptococcus pneumoniae is a common bacterial pathogen causing various diseases in humans and animals. OBJECTIVE The aim of study was to evaluate the role of TNF-α against infection with Streptococcus pneumonia by intratracheal route in lambs as experimental lamb model. MATERIAL AND METHODS Six male un-weaned lambs, aged 1 to 2 months and weighing 5 to 7 kg, were exposed to S. pneumoniae strain ATCC 6303 serotype 3 at 2 × 106 CFU/mL via intratracheal route to induce pneumonia. Pneumonic clinical signs were monitored daily, and blood samples were collected before exposure (day 0) and on days 3, 6, and 14 post-exposures for total and differential WBC counts and tumor necrosis factor-alpha (TNF-α) assessments. Additionally, on days 6 and 14 post-exposure, trachea and lung tissue samples were collected for macroscopic and microscopic pathological evaluation. RESULTS revealed a significant increase (P<0.001) in total WBC counts from day 3 post-exposure, maintaining elevated levels on days 6 and 14 compared to day zero. Differential WBC counts indicated an early, significant rise in neutrophils, with sustained elevation in lymphocytes and monocytes. TNF-α levels peaked on day 3 and gradually declined by day 14 post-exposure, reflecting an acute inflammatory response to the infection Gross pathology at 6-14-days post-exposure showed pulmonary congestion and edema of affected lungs, emphysema, swelling and congestion of trachea. Histopathologically marked epithelial degeneration and necrosis with inflammatory processes in tracheitis and focal interstitial pneumoniae. CONCLUSION the present study concluded the pivotal role of TNF-α in the immune response against Streptococcus pneumoniae infection in lambs | ||
| کلیدواژه‌ها | ||
| Infection؛ Pneumococci؛ pathology؛ lambs | ||
| عنوان مقاله [English] | ||
| نقش TNF-α در عفونت تجربی استرپتوکوک پنومونیه در بره ها | ||
| نویسندگان [English] | ||
| عباس عابدالیماه حمزه؛ زینب اسماعیل ابراهیم | ||
| گروه آسیب شناسی و بیماری های طیور، دانشکده دامپزشکی، دانشگاه بغداد، بغداد، عراق | ||
| کلیدواژه‌ها [English] | ||
| عفونت, پنوموکوک, آسیب شناسی, بره | ||
|
آمار تعداد مشاهده مقاله: 27 تعداد دریافت فایل اصل مقاله: 72 |
||