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Effects on Betaine on ameliorating depression in gonadectomized male rats | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 23 دی 1402 اصل مقاله (426.21 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2023.367753.1005466 | ||
| نویسندگان | ||
| Jina Ghasemi jalal1؛ Shahin Hassanpour* 2 | ||
| 1Undergraduate Student of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Background: Depression is one of the major mental disorders categorized by impairment in mood and Betaine has anti-nociceptive activity in mice. Objectives: This study aimed to determine the anti-depressive activity of betaine in gonadectomized male rats. Methods: Twenty adult male rats were allocated into four experimental groups. Group 1 was kept in control, while in the other groups, castration was done. Group 2 was the sham group had castration with no treatment. In the imipramine group, rats were castrated and administered the imipramine (15 mg/kg) for two weeks. In group 4, following castration, rats were i.p. injected with betaine (30 mg/kg) for two weeks, respectively. Then anti-depressive tests were done using a forced swimming test (FST), tail suspension test (TST), and open field test (OFT). At the end of the study, blood samples were taken from each cardiac mouse, and serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were determined. Results: Based on the findings, castration significantly increased immobility time on FST and TST and the activity of the rat in OFT (P<0.05).Administration of the betaine with castration significantly decreased mobility time on FST and TST and the rat's movement in OFT compared to the untreated group (P<0.05). Castration significantly increased serum MDA levels and decreased SOD, GPx, and CAT levels compared to the control group (P<0.05). Betaine significantly decreased serum MDA levels and enhanced SOD, GPx, and CAT levels compared to the control group (P<0.05). Conclusion: These results suggested betaine, as a natural antioxidant, has a beneficial effect on decreasing castration-induced depressive behaviors. | ||
| کلیدواژه‌ها | ||
| Betaine؛ Depression؛ Castration؛ male؛ Rat | ||
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آمار تعداد مشاهده مقاله: 104 تعداد دریافت فایل اصل مقاله: 188 |
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