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Ghorbani Shemirani, Mahbod, Shirani, Darioush, Jamshidi, Shahram, Nassiri, Seyed Mahdi, Masoudifard, Majid, Mahdipour, Maryam, Banifazl, Sanaz, Vali, Yasamin. (1402). Renal Resistive Index and Renin-Angiotensin-Aldosterone System Components as Early Indicators of Kidney Damage in Persian cat Polycystic Kidney Disease. , (), -. doi: 10.22059/ijvm.2023.364489.1005440
Mahbod Ghorbani Shemirani; Darioush Shirani; Shahram Jamshidi; Seyed Mahdi Nassiri; Majid Masoudifard; Maryam Mahdipour; Sanaz Banifazl; Yasamin Vali. "Renal Resistive Index and Renin-Angiotensin-Aldosterone System Components as Early Indicators of Kidney Damage in Persian cat Polycystic Kidney Disease". , , , 1402, -. doi: 10.22059/ijvm.2023.364489.1005440
Ghorbani Shemirani, Mahbod, Shirani, Darioush, Jamshidi, Shahram, Nassiri, Seyed Mahdi, Masoudifard, Majid, Mahdipour, Maryam, Banifazl, Sanaz, Vali, Yasamin. (1402). 'Renal Resistive Index and Renin-Angiotensin-Aldosterone System Components as Early Indicators of Kidney Damage in Persian cat Polycystic Kidney Disease', , (), pp. -. doi: 10.22059/ijvm.2023.364489.1005440
Ghorbani Shemirani, Mahbod, Shirani, Darioush, Jamshidi, Shahram, Nassiri, Seyed Mahdi, Masoudifard, Majid, Mahdipour, Maryam, Banifazl, Sanaz, Vali, Yasamin. Renal Resistive Index and Renin-Angiotensin-Aldosterone System Components as Early Indicators of Kidney Damage in Persian cat Polycystic Kidney Disease. , 1402; (): -. doi: 10.22059/ijvm.2023.364489.1005440

Renal Resistive Index and Renin-Angiotensin-Aldosterone System Components as Early Indicators of Kidney Damage in Persian cat Polycystic Kidney Disease

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 مهر 1402    اصل مقاله (1.5 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2023.364489.1005440
نویسندگان
Mahbod Ghorbani Shemirani1؛ Darioush Shirani* 1؛ Shahram Jamshidi1؛ Seyed Mahdi Nassiri2؛ Majid Masoudifard3؛ Maryam Mahdipour3؛ Sanaz Banifazl4؛ Yasamin Vali5
1Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
4Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
5Diagnostic imaging, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria
چکیده
Objectives: Polycystic kidney disease (PKD) in Persian cats is a common genetic disorder that accounts for 10% of chronic renal failures. This study aimed to assess the effect of PKD progression on renal resistive index (RI), plasma renin activity (PRA), angiotensin II (ANG II), aldosterone levels and systolic blood pressure in Persian cats.
Methods: Fifty Persian cats (25 PKD and 25 healthy) were included in the present study. The blood pressure of each cat was measured, and then PRA, ANG II, and aldosterone enzymes were evaluated by ELISA test. Additionally, B-Mode ultrasonography was performed in PKD group to evaluate and calculate the diameter and overall volume of cysts (OVC). Furthermore, the RI was computed by pulsed-wave Doppler in all cats.
Results: There were no significant differences in the systolic blood pressure between healthy and PKD cats (138.84±2.89 mmHg and 140.92±2.35 mmHg). PRA, aldosterone, and ANG II were significantly higher in the PKD group compared to the healthy group; 3.64±0.36 vs 2.26±0.029 ng/ml (p<0.01), 80.45±2.35 vs 30.98±1.75 pg/ml (p<0.0001), and 53.54±3.22 vs. 30.08±3.06 pg/ml (p<0.0001), respectively. Statistically significant increases (p<0.0001) were detected in RIs of right and left kidneys in PKD cats (0.72±0.01 and 0.71±0.008, respectively) compared with healthy cats (0.59±0.008 and 0.60±0.008). The statistical analysis showed a strong direct correlation between RI changes and the right or left kidney OVC (p<0.001), in which manifest the correlation between RI increase and renal disease progression.
Conclusion: Increase in renin-angiotensin-aldosterone activity, and RI in Persian cats diagnosed with PKD can be valuable diagnostic tools for their renal disease progression. However, our results showed that the systemic blood pressure is maintained and stays in its normal ranges.
کلیدواژه‌ها
Aldosterone؛ angiotensin II؛ polycystic kidney disease؛ resistive index؛ renin
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