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A New Insight into Salinomycin | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 28 شهریور 1402 اصل مقاله (614.48 K) | ||
| نوع مقاله: Review article | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2023.362649.1005424 | ||
| نویسندگان | ||
| Razieh Hosseini* 1؛ Ali Hajimohammadi2؛ Negar Panahi3؛ Hamid Rajaian4 | ||
| 1Department of Veterinary Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| 3.Department of Veterinary Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 4Department of Pharmacology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran | ||
| چکیده | ||
| Salinomycin is a polyether ionophore antibiotic used as a coccidiostat and growth promoter in veterinary medicine and animal husbandry since the 1980s. It is a promising anticancer drug that targets cancer stem cells in humans and inhibits tumor cell growth. It can induce autophagy, mitophagy, and mitochondrial polarity in cancer cells. Salinomycin can induce cytotoxicity in cancer cells by generating reactive oxygen species (ROS) and inhibiting cyclooxygenase-2 (COX-2) activity. It is also lipid-soluble, which can induce toxicity in humans and various animal species, including bovines, sheep, swine, equines, dogs, and birds. Accidental ingestion of high amounts of salinomycin can lead to cardiac toxicity, neural dysfunction, and paralysis in animals. It can also cause liver damage in animals. Studies have shown that different doses of oral salinomycin alter oxidative stress biomarkers, leading to increased inflammatory biomarkers. Treatment for salinomycin toxicosis often involves supportive care and symptomatic therapy. It is crucial to be cautious when using salinomycin, as it can cause harmful side effects due to its severe toxicity. | ||
| کلیدواژهها | ||
| Anticancer drugs؛ Coccidiostat؛ Ionophores؛ Salinomycin؛ Toxicosis | ||
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