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Kurnianingsih, Nia, Hakim, Ariella, Salsabila, Daffa, Fahanani, Agwin, Harbiyanti, Novita, Ratnawati, Retty. (1402). Total Anthocyanin Extract from Purple Sweet Potato Improves Neurotransmitter and Locomotor Behaviour by Altering Brain Corticosterone in Chronic-Stressed Mice. , (), -. doi: 10.22059/ijvm.2023.360230.1005405
Nia Kurnianingsih; Ariella Ramadhini Hakim; Daffa Salsabila; Agwin Fahmi Fahanani; Novita Titis Harbiyanti; Retty Ratnawati. "Total Anthocyanin Extract from Purple Sweet Potato Improves Neurotransmitter and Locomotor Behaviour by Altering Brain Corticosterone in Chronic-Stressed Mice". , , , 1402, -. doi: 10.22059/ijvm.2023.360230.1005405
Kurnianingsih, Nia, Hakim, Ariella, Salsabila, Daffa, Fahanani, Agwin, Harbiyanti, Novita, Ratnawati, Retty. (1402). 'Total Anthocyanin Extract from Purple Sweet Potato Improves Neurotransmitter and Locomotor Behaviour by Altering Brain Corticosterone in Chronic-Stressed Mice', , (), pp. -. doi: 10.22059/ijvm.2023.360230.1005405
Kurnianingsih, Nia, Hakim, Ariella, Salsabila, Daffa, Fahanani, Agwin, Harbiyanti, Novita, Ratnawati, Retty. Total Anthocyanin Extract from Purple Sweet Potato Improves Neurotransmitter and Locomotor Behaviour by Altering Brain Corticosterone in Chronic-Stressed Mice. , 1402; (): -. doi: 10.22059/ijvm.2023.360230.1005405

Total Anthocyanin Extract from Purple Sweet Potato Improves Neurotransmitter and Locomotor Behaviour by Altering Brain Corticosterone in Chronic-Stressed Mice

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 تیر 1402    اصل مقاله (1.32 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2023.360230.1005405
نویسندگان
Nia Kurnianingsih* 1؛ Ariella Ramadhini Hakim2؛ Daffa Salsabila2؛ Agwin Fahmi Fahanani3؛ Novita Titis Harbiyanti3؛ Retty Ratnawati3
1Department of Physiology, Faculty of Medicine, Universitas Brawijaya, ،Malang, Indonesia- Research Centre of Smart Molecule of Natural Genetics Resources, Universitas Brawijaya, Malang, Indonesia
2Bachelor Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
3Department of Physiology, Faculty of Medicine, Universitas Brawijaya, ،Malang, Indonesia
چکیده
Objectives: Prolonged stress has essential roles on depression disorder through brain inflammation and neurotransmitter imbalances. Natural plant antioxidant is promising to resist the negative impact of stress. This study purposed to analyse the effect of total anthocyanin extracts (ANC) from purple sweet potatoes on brain inflammation, neurotransmitters, and locomotor behaviour of chronic-stressed mice model Methods: Twenty males of adult BALB/c mice were assigned to control; stress; stress + ANC 10 mg/kgBW; stress + ANC 20 mg/kgBW and stress + ANC 40 mg/kgBW. Restraint stress was applicated 2 hours/day for 14 days. Enzyme-linked immunosorbent assay (ELISA) was performed to measure brain corticosterone, dopamine, and gamma-aminobutyric acid (GABA) level. Locomotor behaviour was analysed using open field test at pre- and post-ANC treatment. Molecular docking prediction was performed between ANC and monoamine oxidase-B (MAO-B) enzyme. Results: Administration of ANC decreased brain corticosterone level. Neurotransmitter of dopamine decreased in stress-induced group then increased following ANC treatment. Increased of GABA level observed in stressed and treated groups. Locomotor analysis showed tendencies of reduction of total distance movement and velocity after ANC treatment. Molecular prediction showed ANC has potential to inhibit the MAO-B enzymes. Conclusion: The ANC from PSP relieved brain inflammation and modified the neurotransmitter of dopamine and GABA thus affect the locomotor of chronic stressed-induced mice. Further in vivo studies are necessary to evaluate the molecular mechanism of ANC from PSP in chronic stress exposure particularly on MAO enzyme regulation.
کلیدواژه‌ها
Anthocyanin؛ brain؛ dopamine؛ GABA؛ stress
عنوان مقاله [English]
عصاره آنتوسیانین از سیب زمینی شیرین بنفش با تغییر کورتیکوسترون مغز در موش های تحت استرس مزمن، انتقال دهنده های عصبی و رفتار حرکتی را بهبود می بخشد.
نویسندگان [English]
نیا کورنیانینگ سی1؛ آرلیا رامادینی حکیم2؛ دافا سال سابیلا2؛ آگوین فهمی فهانانی3؛ نویتا تیتیس هربیانتی3؛ رتی راتناواتی3
1گروه فیزیولوژی، دانشکده پزشکی، دانشگاه براویجایا، مالانگ ،اندونزی- مرکز تحقیقات مولکول هوشمند منابع ژنتیک طبیعی، دانشگاه براویجایا، مالانگ، اندونزی
2برنامه لیسانس علوم پزشکی، دانشکده پزشکی، دانشگاه براویجایا،مالانگ، اندونزی
3گروه فیزیولوژی، دانشکده پزشکی، دانشگاه براویجایا، مالانگ ،اندونزی
کلیدواژه‌ها [English]
آنتوسیانین, مغز, دوپامین, گابا, استرس
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