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رسولی جوکار, الهه, شاملو کاظمی, سعید. (1402). تأثیر هشت هفته مکمل چیتوزان و تمرین ترکیبی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا. , 15(1), 55-70. doi: 10.22059/jsb.2023.354853.1574
الهه رسولی جوکار; سعید شاملو کاظمی. "تأثیر هشت هفته مکمل چیتوزان و تمرین ترکیبی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا". , 15, 1, 1402, 55-70. doi: 10.22059/jsb.2023.354853.1574
رسولی جوکار, الهه, شاملو کاظمی, سعید. (1402). 'تأثیر هشت هفته مکمل چیتوزان و تمرین ترکیبی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا', , 15(1), pp. 55-70. doi: 10.22059/jsb.2023.354853.1574
رسولی جوکار, الهه, شاملو کاظمی, سعید. تأثیر هشت هفته مکمل چیتوزان و تمرین ترکیبی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا. , 1402; 15(1): 55-70. doi: 10.22059/jsb.2023.354853.1574

تأثیر هشت هفته مکمل چیتوزان و تمرین ترکیبی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا

نشریه علوم زیستی ورزشی
مقاله 4، دوره 15، شماره 1 - شماره پیاپی 95، اردیبهشت 1402، صفحه 55-70    اصل مقاله (506.67 K)
نوع مقاله: مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I
شناسه دیجیتال (DOI): 10.22059/jsb.2023.354853.1574
نویسندگان
الهه رسولی جوکار1؛ سعید شاملو کاظمی* 2
1گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه دانش البرز، قزوین، ایران .
2نویسندة مسؤول، گروه فیزیولوژی ورزشی، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه بوعلی سینا، همدان، ایران.
چکیده
مقدمه:  فشار خون بالا و دیس لیپیدمی از عوامل خطر بیماری‌های قلبی- عروقی از علل اصلی مرگ‌ومیرند. با این حال، مصرف مکمل‌های گیاهی و انجام فعالیت‌های بدنی می‌تواند به پیشگیری از این بیماری کمک کند. بنابراین تحقیق حاضر به بررسی تأثیر مکمل چیتوزان و ورزش ترکیبی بر فشار خون و پروفایل لیپیدی زنان مبتلا به فشار خون بالا پرداخت.
روش پژوهش: تحقیق به‌صورت کارآزمایی بالینی روی 40 زن مبتلا به فشار خون بالا انجام گرفت. شرکت‌کنندگان به‌طور تصادفی در چهار گروه (10 نفر مکمل چیتوزان-10 نفر تمرین ترکیبی-10 نفر مکمل چیتوزان به‌همراه تمرین ترکیبی و 10 نفر کنترل) قرار گرفتند. شرکت‌کنندگان در گروه تمرین ترکیبی به مدت هشت هفته (سه روز در هفته) تمرین هوازی و پس از آن تمرینات مقاومتی و گروه مکمل و مکمل  با تمرین روزانه 4 گرم چیتوزان (8 کپسول 500 میلی‌گرمی) مصرف کردند. نمونه‌گیری خونی و اندازه‌گیری فشار خون پیش از هشت هفته و دوباره 48 ساعت پس از آخرین جلسۀ تمرین و مکمل‌دهی انجام گرفت. اندازه‌گیری‌ها ثبت شد.
یافته‌ها: تجزیه‌وتحلیل آماری داده‌ها با spss نسخۀ 23 با استفاده از آزمون‌ تحلیل واریانس آنوا و کوواریانس در سطح معناداری (05/0P≤) انجام گرفت. بیشترین مقدار میانگین فشار خون سیستولیک پس از آزمون (8/9±9/141)، کلسترول کل پس از آزمون (9/3±28/213) در افراد شرکت‌کننده در گروه تمرینات ترکیبی مشاهده شد و نتایج مقایسۀ بین گروهی حاکی از بهبود معنا‌دار شاخص‌های فشار خون سیتولیک و کلسترول کل، تری‌گلیسیرید،  VLDL,LDL بود و در شاخص‌های فشار خون دیاستولیک و HDL نتایج نزدیک به سطح معناداری مشاهده شد.
نتیجه‌گیری: در مجموع نتایج نشان داد که مصرف مکمل ‌چیتوزان و تمرین ترکیبی تأثیرات مفیدی بر فشار خون و پروفایل لیپیدی در زنان مبتلا به فشار خون بالا دارد.
کلیدواژه‌ها
پروفایل لیپیدی؛ تمرین ترکیبی؛ چیتوزان؛ فشار خون
عنوان مقاله [English]
Effect of Eight-Weeks Chitosan Supplementation and Combined Exercise on the Blood Pressure and Lipid Profile of Women With Hypertension
نویسندگان [English]
elahe rasuli Jokar1؛ saeid shamlou kazemi2
1Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Danesh Alborz, Univesity of Qazvin, Qazvin, Iran.
2Corresponding Author, Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University of Hamedan, Hamedan, Iran.
چکیده [English]
Introduction: Hypertension and dyslipidemia are risk factors for cardiovascular diseases and are the leading causes of death. However, taking herbal supplements and physical activity engagement can help prevent this disease. Therefore, the present study investigated the effect of chitosan supplementation and combined exercise on blood pressure and lipid profile in women with hypertension.
Methods: The study was conducted as a clinical trial on 40 women with high blood pressure. The participants were randomly divided into four Chitosan Supplement (N=10), Combined Exercise (N=10), Chitosan Supplements + Combined Exercise (N=10), and Control (N=10) groups. For combined exercise, participants performed aerobic exercise for eight weeks (three days a week) followed by resistance training, while for the supplement, participants consumed four grams of Chitosan daily (eight capsules of  500 mg each). Blood sampling and blood pressure measurements were conducted before eight weeks and again 48 hours after the last exercise and supplementation session and all the measurements were recorded.
Results: Statistical analysis of data was done via SPSS version 23 using Analysis of Variance (ANOVA) and Covariance at a significant level of P≤0.05. The highest mean value of post-test systolic blood pressure (141.9±9.8), and post-test total cholesterol (213.28±3.9) was observed in the participants of the Combined Exercise group. The results of the between-group comparison indicated a significant improvement in systolic blood pressure, total cholesterol, triglyceride, VLDL, and LDL indices. In diastolic blood pressure and HDL indices, the results were close to the significant level.
Conclusion: Overall, the results showed that the consumption of Chitosan supplements and combined exercise have beneficial effects on the blood pressure and lipid profile of women with high blood pressure.
کلیدواژه‌ها [English]
Blood pressure, Chitosan, Combined exercise, Lipid profile
مراجع

1.Hernández-Lepe MA, Olivas-Aguirre FJ, Gómez-Miranda LM, Hernández-Torres RP, Manríquez-Torres JdJ, Ramos-Jiménez A. Systematic physical exercise and Spirulina maxima supplementation improve body composition, cardiorespiratory fitness, and blood lipid profile: Correlations of a randomized double-blind controlled trial. Antioxidants. 2019;8(11):507. 10.3390/antiox8110507

2.Huang H, Zou Y, Chi H. Quantitative assessment of the effects of chitosan intervention on blood pressure control. Drug Design, Development and Therapy. 2017:67-75. 10.2147/dddt.s148064

3.Huang H, Liao D, Pu R, Cui Y. Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure. Diabetes, metabolic syndrome and obesity: targets and therapy. 2018;11:729. 10.2147/dmso.s185672

4.Choudhury KN, Mainuddin A, Wahiduzzaman M, Islam SMS. Serum lipid profile and its association with hypertension in Bangladesh. Vascular health and risk management. 2014;10:327. 10.2147/vhrm.s61019

5.Nwabuo CC, Vasan RS. Pathophysiology of hypertensive heart disease: beyond left ventricular hypertrophy. Current hypertension reports. 2020;22(2):1-18.10.1007/s11906-020-1017-9

6.Moraru C, Mincea MM, Frandes M, Timar B, Ostafe V. A meta-analysis on randomised controlled clinical trials evaluating the effect of the dietary supplement chitosan on weight loss, lipid parameters and blood pressure. Medicina. 2018;54(6):109. 10.3390/medicina54060109

7.Sharman JE, Smart NA, Coombes JS, Stowasser M. Exercise and sport science australia position stand update on exercise and hypertension. Journal of human hypertension. 2019;33(12):837-43.10.1038/s41371-019-0266-z

8.Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, `````synthesis and recommendations. Sports medicine. 2014;44:211-21. 10.1007/s40279-013-0110-5

9.Theodorou AA, Panayiotou G, Volaklis KA, Douda HT, Paschalis V, Nikolaidis MG, et al. Aerobic, resistance and combined training and detraining on body composition, muscle strength, lipid profile and inflammation in coronary artery disease patients. Research in sports medicine. 2016;24(3):171-84. 10.1080/15438627.2016.1191488

10.Huang H, Zou Y, Chi H, Liao D. Lipid‐Modifying Effects of Chitosan Supplementation in Humans: A Pooled Analysis with Trial Sequential Analysis. Molecular nutrition & food research. 2018;62(8):1700842. https://doi.org/10.1002/mnfr.201700842

11.Cheung RC, Ng TB, Wong JH, Chan WY. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015;13(8):5156-86.

12.Koide S. Chitin-chitosan: properties, benefits and risks. Nutrition research. 1998;18(6):1091-101. 10.1016/S0271-5317(98)00091-8

13.Auwal SM, Zarei M, Tan CP, Basri M, Saari N. Improved in vivo efficacy of anti-hypertensive biopeptides encapsulated in chitosan nanoparticles fabricated by ionotropic gelation on spontaneously hypertensive rats. Nanomaterials. 2017;7(12):421. 10.3390/nano7120421

14.Je JY, Park PJ, Kim B, Kim SK. Antihypertensive activity of chitin derivatives. Biopolymers: Original Research on Biomolecules. 2006;83(3):250-4. 10.1002/bip.20553

15.Schroeder EC, Franke WD, Sharp RL, Lee D-c. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial. PloS one. 2019;14(1):e0210292. journal.pone.021029210.1371/Journal.pone.0210292

16.Leandro MPG, Moura JLSd, Barros GWP, Silva APd, Farias ACdO, Carvalho PRC. Effect of the aerobic component of combined training on the blood pressure of hypertensive elderly women. Revista Brasileira de Medicina do Esporte. 2019;25:469-73. 10.1590/1517-869220192506214228

17.Dehghani A, Momeni Z, Fallahzadeh H, Dafei M, Hekmatimoghaddam H, Mojibian M, et al. Compare Lipid Profile and Anthropometric Indices and Blood Pressure in Women with and without Low-Dose Birth Control Pills. J Tolooebehdasht Sci. 2017;15(1):85-97.

18.Szulinska M, Gibas-Dorna M, Miller-Kasprzak E, Suliburska J, Miczke A, Walczak-Gałezewska M, et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci. 2017;21(10):2473-81.

19.Naderifar H, Mohammad khani Gangeh M, Mehri F, Shamloo Kazemi S. Effects of High Intensity Interval Training and Consumption of Matcha Green Tea on Malondialdehyde and Glutathione Peroxidase Levels in women. Journal of Mazandaran University of Medical Sciences. 2022;32(212):42-53. https://jmums.mazums.ac.ir/article-1-18008-en.html

20.Miladi Ghomi H, Abedi B, Ramezani S. The effect of a period of circular resistance training on serum perptin levels and insulin resistance in men with type 2 diabetes. Journal of Sport Biosciences. 2021;13(3):383-97. https://doi.org/10.22059/jsb.2021.321277.1462

21.Huang H, Zou Y, Chi H. Quantitative assessment of the effects of chitosan intervention on blood pressure control. Drug Design, Development and Therapy. 2018;12:67. 10.2147/dddt.s148064

22.Eskandari M, Pournemati P, Hooshmand Moghadam B, Norouzi J. The interactive effect of aerobic exercise and supplementation of blue-algae (Spirulina) on anthropometric indexes and cardiovascular risk factors in diabetic men. Sadra Medical Journal. 2019;8(1):51-62. 10.30476/smsj.2020.83630.1068

23.Du M, Kou L, Li S. Water-soluble chitosan regulates vascular remodeling in hypertension via NFATc1. European Heart Journal Supplements. 2016;18(suppl_F):F38-F. 10.1093/eurheartj/suw037

24.Allaert F. Double-blind, randomized, crossover, controlled clinical trial of NaCl+ Chitosan 3% versus NaCl on mild or moderate high blood pressure during the diet and lifestyle improvement period before possible prescription of an antihypertensive treatment. International Angiology. 2013;32(1):94-101. 10.1016/j.acvdsp.2019.05.098

25.Ausar S, Morcillo M, León A, Ribotta P, Masih R, Vilaro Mainero M, et al. Improvement of HDL-and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan. Journal of Medicinal Food. 2003;6(4):397-9. 10.1089/109662003772519985

26.Rizzo M, Giglio RV, Nikolic D, Patti AM, Campanella C, Cocchi M, et al. Effects of chitosan on plasma lipids and lipoproteins: a 4-month prospective pilot study. Angiology. 2014;65(6):538-42. https://doi.org/10.1177/0003319713493126

27.Huang H, Liao D, Zou Y, Chi H. The effects of chitosan supplementation on body weight and body composition: a systematic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition. 2020;60(11):1815-25. 10.1080/10408398.2019.1602822

28.Trivedi V, Satia M, Deschamps A, Maquet V, Shah R, Zinzuwadia P, et al. Single-blind, placebo controlled randomised clinical study of chitosan for body weight reduction. Nutrition journal. 2015;15(1):1-12. 10.1186/s12937-016-0122-8

29.Son W-M, Sung K-D, Cho J-M, Park S-Y. Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension. Menopause. 2017;24(3):262-8. 10.1097/gme.0000000000000765

30.Pires NF, Coelho-Júnior HJ, Gambassi BB, de Faria APC, Ritter AMV, de Andrade Barboza C, et al. Combined aerobic and resistance exercises evokes longer reductions on ambulatory blood pressure in resistant hypertension: a randomized crossover trial. Cardiovascular therapeutics. 2020;2020. 10.1155/2020/8157858

31.Pedralli ML, Marschner RA, Kollet DP, Neto SG, Eibel B, Tanaka H, et al. Different exercise training modalities produce similar endothelial function improvements in individuals with prehypertension or hypertension: A randomized clinical trial. Scientific reports. 2020;10(1):1-9. 10.1038/s41598-020-64365-x

32.Boeno FP, Ramis TR, Munhoz SV, Farinha JB, Moritz CE, Leal-Menezes R, et al. Effect of aerobic and resistance exercise training on inflammation, endothelial function and ambulatory blood pressure in middle-aged hypertensive patients. Journal of Hypertension. 2020;38(12):2501-9. 10.1097/hjh.0000000000002581

33.Collier S, Kanaley J, Carhart R, Frechette V, Tobin M, Hall A, et al. Effect of 4 weeks of aerobic or resistance exercise training on arterial stiffness, blood flow and blood pressure in pre-and stage-1 hypertensives. Journal of human hypertension. 2008;22(10):678-86. 10.1038/jhh.2008.36

34.Cardoso Jr CG, Gomides RS, Queiroz ACC, Pinto LG, da Silveira Lobo F, Tinucci T, et al. Acute and chronic effects of aerobic and resistance exercise on ambulatory blood pressure. Clinics. 2010;65(3):317-25. 10.1590/S1807-59322010000300013

35.da Silva RS, da Silva DS, Waclawovsky G, Schaun MI. Effects of aerobic, resistance, and combined training on endothelial function and arterial stiffness in older adults: study protocol for a systematic review and meta-analysis. Systematic Reviews. 2022;11(1):1-9. 10.1186/s13643-022-02036-w

36.Li G, Lv Y, Su Q, You Q, Yu L. The effect of aerobic exercise on pulse wave velocity in middle-aged and elderly people: A systematic review and meta-analysis of randomized controlled trials. Frontiers in cardiovascular medicine. 2022;9:960096. 10.3389%2Ffcvm.2022.960096

37.Lee HS, Lee J. Effects of combined exercise and low carbohydrate ketogenic diet interventions on waist circumference and triglycerides in overweight and obese individuals: a systematic review and meta-analysis. International journal of environmental research and public health. 2021;18(2):828. 10.3390/ijerph18020828

38.Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports medicine. 2014;44(2):211-21. 10.1007/s40279-013-0110-5

39.Rossi FE, Fortaleza AC, Neves LM, Buonani C, Picolo MR, Diniz TA, et al. Combined train ing (aerobic plus strength) potentiates a reduction in body fat but demonstrates no difference on the lipid profile in postmenopausal women when compared with aerobic training with a similar training load. The Journal of Strength & Conditioning Research. 2016;30(1):226-34. 10.1519/jsc.0000000000001020

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