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Salimi, Dariush, salimi, mohaddese, Moieni, Ali. (1401). Distribution of RNA 5-mers in Epigenetic Modification Regions and Genes Interactions. , 54(2), 143-162. doi: 10.22059/jac.2022.91076
Dariush Salimi; mohaddese salimi; Ali Moieni. "Distribution of RNA 5-mers in Epigenetic Modification Regions and Genes Interactions". , 54, 2, 1401, 143-162. doi: 10.22059/jac.2022.91076
Salimi, Dariush, salimi, mohaddese, Moieni, Ali. (1401). 'Distribution of RNA 5-mers in Epigenetic Modification Regions and Genes Interactions', , 54(2), pp. 143-162. doi: 10.22059/jac.2022.91076
Salimi, Dariush, salimi, mohaddese, Moieni, Ali. Distribution of RNA 5-mers in Epigenetic Modification Regions and Genes Interactions. , 1401; 54(2): 143-162. doi: 10.22059/jac.2022.91076

Distribution of RNA 5-mers in Epigenetic Modification Regions and Genes Interactions

Journal of Algorithms and Computation
دوره 54، شماره 2، اسفند 2022، صفحه 143-162    اصل مقاله (1.64 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/jac.2022.91076
نویسندگان
Dariush Salimi* 1؛ mohaddese salimi2؛ Ali Moieni3
1Department of Computer Engineering, Faculty of engineering, Zanjan University,Zanjan, Iran
2Department of Computer Engineering, Faculty of Engineering, Zanjan University, Zanjan, Iran
3Department of Algorithms and Computation, Faculty of Engineering Science, College of Engineering, University of Tehran
چکیده
The demand for extracting sophisticated features, capable of effectively predicting gene interaction networks, from DNA or RNA sequences has increased in computational biology. The epigenetic modifications along with their patterns have been intensely recognized as appealing features affecting gene interaction. However, studying sequenced-based features highly correlated to this key element has remained limited. In this paper, the classification of 23 genes in the PPAR signaling pathway associated with muscle fat tissue in humans was proposed based on statistical distributions of the specified RNA-5-mers abundance. Then, we suggested that these 5-mers highly correlated to epigenetic modifications can efficiently categorize the different gene interactions, particularly co-expression interaction and physical interaction. Our results were evaluated according to GeneMania web interface shows that the geometric distribution of 5 mers in the epigenetic modifications region indicates the proportion of most physical interactions and the Poisson distribution the proportion of most Co-expression between genes
 
کلیدواژه‌ها
5-mers distributes؛ epigenetics modifications؛ genes interactions
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