Nekounam, Houra, Dinarvand, Rassoul, Khademi, Rahele, Asghari, Fatemeh, Mahmoodi, Narges, Arzani, Hossein, Hasanzadeh, Elham, Hadi, Amin, Karimi, Roya, Kamali, Morteza, Khosravani, Masood. (1400). Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.. , 52(3), 498-506. doi: 10.22059/jcamech.2021.322424.641
Houra Nekounam; Rassoul Dinarvand; Rahele Khademi; Fatemeh Asghari; Narges Mahmoodi; Hossein Arzani; Elham Hasanzadeh; Amin Hadi; Roya Karimi; Morteza Kamali; Masood Khosravani. "Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.". , 52, 3, 1400, 498-506. doi: 10.22059/jcamech.2021.322424.641
Nekounam, Houra, Dinarvand, Rassoul, Khademi, Rahele, Asghari, Fatemeh, Mahmoodi, Narges, Arzani, Hossein, Hasanzadeh, Elham, Hadi, Amin, Karimi, Roya, Kamali, Morteza, Khosravani, Masood. (1400). 'Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.', , 52(3), pp. 498-506. doi: 10.22059/jcamech.2021.322424.641
Nekounam, Houra, Dinarvand, Rassoul, Khademi, Rahele, Asghari, Fatemeh, Mahmoodi, Narges, Arzani, Hossein, Hasanzadeh, Elham, Hadi, Amin, Karimi, Roya, Kamali, Morteza, Khosravani, Masood. Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.. , 1400; 52(3): 498-506. doi: 10.22059/jcamech.2021.322424.641

Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer.

Journal of Computational Applied Mechanics
دوره 52، شماره 3، آذر 2021، صفحه 498-506    اصل مقاله (638.84 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/jcamech.2021.322424.641
نویسندگان
Houra Nekounam1؛ Rassoul Dinarvand2، 3؛ Rahele Khademi4؛ Fatemeh Asghari1؛ Narges Mahmoodi5؛ Hossein Arzani1؛ Elham Hasanzadeh6؛ Amin Hadi7؛ Roya Karimi8؛ Morteza Kamali1؛ Masood Khosravani* 1
1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
4International affairs, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
6Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
7Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
8Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach (with chemical and mechanical base) for improvement the surface chemistry of albumin and the amount of indirubin loaded CHSA nanoparticle. In this study, the generated mechanical force from a high-pressure homogenizer (HPH) was used to make nanoparticles with a certain size with narrow polydispersity. The results indicated that the size of indirubin loaded CHSA nanoparticles were 130 nm and their zeta potential were +9. Besides, the encapsulation efficiency and drug loading capacity were found to be 85% and 5.8 %, respectively. To the best to our knowledge, this is the first time that indirubin has been used in albumin nanoparticles. In this study, indirubin loaded CHSA nanoparticles was shown can be a potential candidate for drug delivery in the treatment of glioblastoma. Moreover, the cationized form allows the chemical agent to be transmitted to the brain.
کلیدواژه‌ها
Brain Tumor؛ Cationated Human Serum Albumin؛ Indirubin, Glioblastoma؛ Protein Nanoparticles؛ Sustained release
مراجع
آمار
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