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تأثیر دوازده هفته تمرین تناوبی شدید بر پویایی میتوکندریایی میوسیتهای قلبی رتهای دیابتی نوع2 | ||
نشریه علوم زیستی ورزشی | ||
مقاله 3، دوره 13، شماره 1، خرداد 1400، صفحه 25-38 اصل مقاله (338.96 K) | ||
نوع مقاله: مقاله پژوهشی Released under CC BY-NC 4.0 license I Open Access I | ||
شناسه دیجیتال (DOI): 10.22059/jsb.2021.223538.1134 | ||
نویسندگان | ||
ساقی زعفرانیه* 1؛ رحمان سوری2 | ||
1کارشناس ارشد دانشکده تربیت بدنی و علوم ورزشی دانشگاه تهران، تهران، ایران | ||
2استاد تمام دانشکده تربیت بدنی و علوم ورزشی دانشگاه تهران، تهران، ایران | ||
چکیده | ||
هدف از پژوهش حاضر بررسی تأثیر 12 هفته تمرین تناوبی شدید بر بیان ژنهای DRP1, MFN2 و OPA1 در عضلۀ قلبی رتهای نر ویستار دیابتی نوع 2 بود. بدینمنظور 20 سر رت 10 هفتهای (با میانگین وزن 20±220 گرم) بهصورت تصادفی به 2 گروه 10 تایی کنترل دیابتی و دیابتی با تمرین تناوبی شدید تقسیم شدند. برنامۀ تمرینی به مدت 12 هفته و هفتهای 5 جلسه با مدت و سرعت مشخص اجرا شد. 48 ساعت پس از آخرین جلسۀ تمرینی، عضلۀ بطن قلب حیوانات از بطن جهت آزمایشهای ژنتیک جدا شد. نتایج پژوهش با استفاده از آزمون T مستقل (05/0P≤) تجزیهوتحلیل شد. نتایج نشان داد که تفاوت معناداری در بیان ژن MFN2 میان گروههای کنترل دیابتی و دیابتی تمرینی وجود نداشت (337/0=P)، اما 12 هفته تمرین به افزایش معنادار بیان ژن پروتئینهای DRP1 (001/0=P) و OPA1 (001/0=P) در رتهای دیابتی منجر شد. بهطور کلی میتوان گفت که تمرین ورزشی تناوبی شدید ممکن است بیان ژنهای مربوط به پویایی میتوکندریایی را در بیماری دیابت بهطور مثبتی تنظیم کند. | ||
کلیدواژهها | ||
بیان ژن؛ پویایی میتوکندری؛ تمرین تناوبی؛ دیابت | ||
مراجع | ||
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