سامانه پشتیبانی خدمات اطلاعات

  اخبار و اعلانات

 آمار

تعداد نشریات161
تعداد شماره‌ها6,532
تعداد مقالات70,501
تعداد مشاهده مقاله124,099,365
تعداد دریافت فایل اصل مقاله97,206,872
Sarvari, Raana, Nouri, Mohammad, Roshangar, Leila, Gholami Farashah, Mohammad Sadegh, Sadrhaghighi, Amirhouman, Agbolaghi, Samira, Keyhanvar, Peyman. (1400). Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof. , 54(1), 64-72. doi: 10.22059/jufgnsm.2021.01.07
Raana Sarvari; Mohammad Nouri; Leila Roshangar; Mohammad Sadegh Gholami Farashah; Amirhouman Sadrhaghighi; Samira Agbolaghi; Peyman Keyhanvar. "Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof". , 54, 1, 1400, 64-72. doi: 10.22059/jufgnsm.2021.01.07
Sarvari, Raana, Nouri, Mohammad, Roshangar, Leila, Gholami Farashah, Mohammad Sadegh, Sadrhaghighi, Amirhouman, Agbolaghi, Samira, Keyhanvar, Peyman. (1400). 'Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof', , 54(1), pp. 64-72. doi: 10.22059/jufgnsm.2021.01.07
Sarvari, Raana, Nouri, Mohammad, Roshangar, Leila, Gholami Farashah, Mohammad Sadegh, Sadrhaghighi, Amirhouman, Agbolaghi, Samira, Keyhanvar, Peyman. Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof. , 1400; 54(1): 64-72. doi: 10.22059/jufgnsm.2021.01.07

Conductive Bio-Copolymers based on Pectin-Polycaprolactone/Polyaniline and Tissue Engineering Application Thereof

Journal of Ultrafine Grained and Nanostructured Materials
دوره 54، شماره 1، شهریور 2021، صفحه 64-72    اصل مقاله (1.85 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/jufgnsm.2021.01.07
نویسندگان
Raana Sarvari1؛ Mohammad Nouri2؛ Leila Roshangar3؛ Mohammad Sadegh Gholami Farashah3؛ Amirhouman Sadrhaghighi4؛ Samira Agbolaghi5؛ Peyman Keyhanvar* 6
1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5Chemical Engineering Department, Faculty of Engineering, Azarbaijan Shahid Madani University, Tabriz, Iran
6Stem Cell Research Center, Stem Cells and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical
چکیده
Development of biopolymers possessing both biodegradable and electrically conducting properties has attracted a huge interest in the biomedical field. These systems have some benefitials in wound healing and reducing the long-term health risks. In this study, the pectin-polycaprolactone (Pec-PCL) copolymers were synthesized by ring-opening polymerization. Subsequently, the solutions of the synthesized Pec-PCL and homopolyaniline (H-PANI) were blended in various ratios and their conductivity properties were measured by cyclic voltammetry and the composition of 80:20 was selected for electrospinning process because of the suitable electroactive behavior and biodegradability. The morphology, biocompatibility, hydrophilicity, and mechanical properties of the nanofibers were thoroughly investigated. Resulted scaffolds represented a porous structure with large surface area (110–130 nm) and Young’s modulus of 1615 ± 32 MPa, which imitated the natural microenvironment of extra cellular matrix (ECM) to regulate the cell attachment, proliferation and differentiation. The results demonstrated that these electrospun nanofibers could be potentially applied in biomedical such as tissue engineering.
کلیدواژه‌ها
Conductive polymer؛ pectin؛ PCL؛ polyaniline؛ biodegradability
مراجع

1. Boyce ST. Regulatory Issues and Standardization. Methods of Tissue Engineering: Elsevier; 2002. p. 3-17.

2. Vahedi P, Jarolmasjed S, Shafaei H, Roshangar L, Soleimani Rad J, Ahmadian E. In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold. Tissue and Cell. 2019;57:49-56.

3. Vahedi P, Soleimanirad J, Roshangar L, Shafaei H, Jarolmasjed S, Nozad Charoudeh H. Advantages of Sheep Infrapatellar Fat Pad Adipose Tissue Derived Stem Cells in Tissue Engineering. Adv Pharm Bull. 2016;6(1):105-10.

4. Levenberg S, Langer R. Advances in Tissue Engineering. Current Topics in Developmental Biology: Elsevier; 2004. p. 113-34.

5. Roushangar Zineh B, Shabgard MR, Roshangar L. Mechanical and biological performance of printed alginate/methylcellulose/halloysite nanotube/polyvinylidene fluoride bio-scaffolds. Materials Science and Engineering: C. 2018;92:779-89.

6. Mahmoudi M, Zhao M, Matsuura Y, Laurent S, Yang PC, Bernstein D, et al. Infection-resistant MRI-visible scaffolds for tissue engineering applications. Bioimpacts. 2016;6(2):111-5.

7. Safari B, Aghanejad A, Roshangar L, Davaran S. Osteogenic effects of the bioactive small molecules and minerals in the scaffold-based bone tissue engineering. Colloids and Surfaces B: Biointerfaces. 2020;198:111462.

8. Sanie-Jahromi F, Eghtedari M, Mirzaei E, Jalalpour MH, Asvar Z, Nejabat M, et al. Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model. Bioimpacts. 2020;10(1):45-54.

9. Lee J, Cuddihy MJ, Kotov NA. Three-Dimensional Cell Culture Matrices: State of the Art. Tissue Engineering Part B: Reviews. 2008;14(1):61-86.

10. Dado D, Levenberg S. Cell–scaffold mechanical interplay within engineered tissue. Seminars in Cell & Developmental Biology. 2009;20(6):656-64.

11. Brown RA, Phillips JB. Cell Responses to Biomimetic Protein Scaffolds Used in Tissue Repair and Engineering. International Review of Cytology: Elsevier; 2007. p. 75-150.

12. Song E, Yeon Kim S, Chun T, Byun H-J, Lee YM. Collagen scaffolds derived from a marine source and their biocompatibility. Biomaterials. 2006;27(15):2951-61.

13. Rahimi-Sherbaf F, Nadri S, Rahmani A, Dabiri Oskoei A. Placenta mesenchymal stem cells differentiation toward neuronal-like cells on nanofibrous scaffold. BioImpacts. 2020;10(2):117-22.

14. Roushangar Zineh B, Shabgard MR, Roshangar L, Jahani K. Experimental and numerical study on the performance of printed alginate/hyaluronic acid/halloysite nanotube/polyvinylidene fluoride bio-scaffolds. Journal of Biomechanics. 2020;104:109764.

15. Nikpou P, Soleimani Rad J, Mohammad Nejad D, Samadi N, Roshangar L, Navali AM, et al. Indirect coculture of stem cells with fetal chondrons using PCL electrospun nanofiber scaffolds. Artificial Cells, Nanomedicine, and Biotechnology. 2016;45(2):283-90.

16. Sarvari R, Keyhanvar P, Agbolaghi S, Gholami Farashah MS, Sadrhaghighi A, Nouri M, et al. Shape-memory materials and their clinical applications. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020:1-21.

17. Samiei M, Aghazadeh M, Alizadeh E, Aslaminabadi N, Davaran S, Shirazi S, et al. Osteogenic/Odontogenic Bioengineering with co-Administration of Simvastatin and Hydroxyapatite on Poly Caprolactone Based Nanofibrous Scaffold. Adv Pharm Bull. 2016;6(3):353-65.

18. Mohammadi F, Mohammadi Samani S, Tanideh N, Ahmadi F. Hybrid Scaffolds of Hyaluronic Acid and Collagen Loaded with Prednisolone: an Interesting System for Osteoarthritis. Adv Pharm Bull. 2018;8(1):11-9.

19. Roushangar Zineh B, Shabgard MR, Roshangar L. An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds. Adv Pharm Bull. 2018;8(4):643-55.

20. Sangsen Y, Benjakul S, Oungbho K. Fabrication of novel shark collagen-pectin scaffolds for tissue engineering.  The 4th 2011 Biomedical Engineering International Conference; 2012/01: IEEE; 2012.

21. Turnbull G, Clarke J, Picard F, Riches P, Jia L, Han F, et al. 3D bioactive composite scaffolds for bone tissue engineering. Bioact Mater. 2017;3(3):278-314.

22. Bigucci F, Luppi B, Cerchiara T, Sorrenti M, Bettinetti G, Rodriguez L, et al. Chitosan/pectin polyelectrolyte complexes: Selection of suitable preparative conditions for colon-specific delivery of vancomycin. European Journal of Pharmaceutical Sciences. 2008;35(5):435-41.

23. Coimbra P, Ferreira P, de Sousa HC, Batista P, Rodrigues MA, Correia IJ, et al. Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications. International Journal of Biological Macromolecules. 2011;48(1):112-8.

24. Il?ina AV, Varlamov VP. Chitosan-based polyelectrolyte complexes: A review. Applied Biochemistry and Microbiology. 2005;41(1):5-11.

25. Langer R, Vacanti J. Tissue engineering. Science. 1993;260(5110):920-6.

26. diZerega GS. Peritoneal repair and post-surgical adhesion formation. Human Reproduction Update. 2001;7(6):547-55.

27. Almeida EAMS, Facchi SP, Martins AF, Nocchi S, Schuquel ITA, Nakamura CV, et al. Synthesis and characterization of pectin derivative with antitumor property against Caco-2 colon cancer cells. Carbohydrate Polymers. 2015;115:139-45.

28. Chen C-H, Sheu M-T, Chen T-F, Wang Y-C, Hou W-C, Liu D-Z, et al. Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways. Biochemical Pharmacology. 2006;72(8):1001-9.

29. Salman H, Bergman M, Djaldetti M, Orlin J, Bessler H. Citrus pectin affects cytokine production by human peripheral blood mononuclear cells. Biomedicine & Pharmacotherapy. 2008;62(9):579-82.

30. Thakur BR, Singh RK, Handa AK, Rao MA. Chemistry and uses of pectin — A review. Critical Reviews in Food Science and Nutrition. 1997;37(1):47-73.

31. Van Vlierberghe S, Dubruel P, Schacht E. Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review. Biomacromolecules. 2011;12(5):1387-408.

32. Richert L, Boulmedais F, Lavalle P, Mutterer J, Ferreux E, Decher G, et al. Improvement of Stability and Cell Adhesion Properties of Polyelectrolyte Multilayer Films by Chemical Cross-Linking. Biomacromolecules. 2004;5(2):284-94.

33. Kulikouskaya V, Kraskouski A, Hileuskaya K, Zhura A, Tratsyak S, Agabekov V. Fabrication and characterization of pectin‐based three‐dimensional porous scaffolds suitable for treatment of peritoneal adhesions. Journal of Biomedical Materials Research Part A. 2019.

34. Massoumi B, Sarvari R, Zareh A, Beygi-Khosrowshahi Y, Agbolaghi S. Polyanizidine and Polycaprolactone Nanofibers for Designing the Conductive Scaffolds. Fibers and Polymers. 2018;19(10):2157-68.

35. Massoumi B, Sarvari R, Agbolaghi S. Biodegradable and conductive hyperbranched terpolymers based on aliphatic polyester, poly(D,L-lactide), and polyaniline used as scaffold in tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(13):808-21.

36. Goldman R, Pollack S. Electric fields and proliferation in a chronic wound model. Bioelectromagnetics. 1996;17(6):450-7.

37. Sisken BF, Walker J, Orgel M. Prospects on clinical applications of electrical stimulation for nerve regeneration. Journal of Cellular Biochemistry. 1993;51(4):404-9.

38. Politis MJ, Zanakis MF. The Short-Term Effects of Delayed Application of Electric Fields in the Damaged Rodent Spinal Cord. Neurosurgery. 1989;25(1):71-5.

39. He J, Wang X-M, Spector M, Cui F-Z. Scaffolds for central nervous system tissue engineering. Frontiers of Materials Science. 2012;6(1):1-25.

40. Ghasemi-Mobarakeh L, Prabhakaran MP, Morshed M, Nasr-Esfahani MH, Baharvand H, Kiani S, et al. Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2011;5(4):e17-e35.

41. Massoumi B, Sarvari R, Zareh A, Beygi-Khosrowshahi Y, Agbolaghi S. Polyanizidine and Polycaprolactone Nanofibers for Designing the Conductive Scaffolds Fibers and Polymers. 2018;19(10):2157-68.

42. Hatamzadeh M, Sarvari R, Massoumi B, Agbolaghi S, Samadian F. Liver tissue engineering via hyperbranched polypyrrole scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020;69(17):1112-22.

43. Cui Y, Wu Q, He J, Li M, Zhang Z, Qiu Y. Porous nano-minerals substituted apatite/chitin/pectin nanocomposites scaffolds for bone tissue engineering. Arabian Journal of Chemistry. 2020;13(10):7418-29.

44. Sarvari R, Massoumi B, Zareh A, Beygi-Khosrowshahi Y, Agbolaghi S. Porous conductive and biocompatible scaffolds on the basis of polycaprolactone and polythiophene for scaffolding. Polymer Bulletin. 2019;77(4):1829-46.

45. Pullar CE, Isseroff RR, Nuccitelli R. Cyclic AMP-dependent protein kinase A plays a role in the directed migration of human keratinocytes in a DC electric field. Cell Motility and the Cytoskeleton. 2001;50(4):207-17.

46. Brown MJ, Loew LM. Electric field-directed fibroblast locomotion involves cell surface molecular reorganization and is calcium independent. J Cell Biol. 1994;127(1):117-28.

47. Ozawa H, Abe E, Shibasaki Y, Fukuhara T, Suda T. Electric fields stimulate DNA synthesis of mouse osteoblast-like cells (MC3T3-E1) by a mechanism involving calcium ions. Journal of Cellular Physiology. 1989;138(3):477-83.

48. McBain VA, Forrester JV, McCaig CD. HGF, MAPK, and a Small Physiological Electric Field Interact during Corneal Epithelial Cell Migration. Investigative Opthalmology & Visual Science. 2003;44(2):540.

49. Shi G, Rouabhia M, Wang Z, Dao LH, Zhang Z. A novel electrically conductive and biodegradable composite made of polypyrrole nanoparticles and polylactide. Biomaterials. 2004;25(13):2477-88.

50. Ahmad N, MacDiarmid AG. Inhibition of corrosion of steels with the exploitation of conducting polymers. Synthetic Metals. 1996;78(2):103-10.

51. MacDiarmid AG, Yang LS, Huang WS, Humphrey BD. Polyaniline: Electrochemistry and application to rechargeable batteries. Synthetic Metals. 1987;18(1-3):393-8.

52. Sivaraman P, Hande VR, Mishra VS, Rao CS, Samui AB. All-solid supercapacitor based on polyaniline and sulfonated poly(ether ether ketone). Journal of Power Sources. 2003;124(1):351-4.

53. Huang J, Virji S, Weiller BH, Kaner RB. Polyaniline Nanofibers:  Facile Synthesis and Chemical Sensors. Journal of the American Chemical Society. 2003;125(2):314-5.

54. Huang J, Virji S, Weiller BH, Kaner RB. Nanostructured Polyaniline Sensors. Chemistry - A European Journal. 2004;10(6):1314-9.

55. Kaner RB. Gas, liquid and enantiomeric separations using polyaniline. Synthetic Metals. 2001;125(1):65-71.

56. Huang S-C, Ball IJ, Kaner RB. Polyaniline Membranes for Pervaporation of Carboxylic Acids and Water. Macromolecules. 1998;31(16):5456-64.

57. Maziarz EP, Lorenz SA, White TP, Wood TD. Polyaniline: A conductive polymer coating for durable nanospray emitters. Journal of the American Society for Mass Spectrometry. 2000;11(7):659-63.

58. Joo J, Epstein AJ. Electromagnetic radiation shielding by intrinsically conducting polymers. Applied Physics Letters. 1994;65(18):2278-80.

59. Wang CH, Dong YQ, Sengothi K, Tan KL, Kang ET. In-vivo tissue response to polyaniline. Synthetic Metals. 1999;102(1-3):1313-4.

60. Wei, Y., Lelkes, P.I., MacDiarmid, A.G., Guterman, E., Cheng, S., Palouian, K. and Bidez, P., 2004. Electroactive polymers and nanostructured materials for neural tissue engineering. Contemporary Topics in Advanced Polymer Science and Technology, pp.430-436.

61. Kamalesh S, Tan P, Wang J, Lee T, Kang E-T, Wang C-H. Biocompatibility of electroactive polymers in tissues. Journal of Biomedical Materials Research. 2000;52(3):467-78.

62. Guterman E, Cheng S, Palouian K, Bidez P, Lelkes P, Wei Y. Peptide-modified electroactive polymers for tissue engineering applications. InABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2002 Aug 18 (Vol. 224, pp. U433-U433). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.

63. Bidez PR, Li S, MacDiarmid AG, Venancio EC, Wei Y, Lelkes PI. Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts. Journal of Biomaterials Science, Polymer Edition. 2006;17(1-2):199-212.

64. Sarvari R, Agbolaghi S, Beygi-Khosrowshahi Y, Massoumi B. Towards skin tissue engineering using poly(2-hydroxy ethyl methacrylate)-co-poly(N-isopropylacrylamide)-co-poly(ε-caprolactone) hydrophilic terpolymers. International Journal of Polymeric Materials and Polymeric Biomaterials. 2019;68(12):691-700.

آمار
تعداد مشاهده مقاله: 1,087
تعداد دریافت فایل اصل مقاله: 572


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب