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Heidary Alizadeh, B., Dehghan, Gh., Derakhsh Ahmadi, V., Moghimi, S., Asadipour, A., Foroumadi, A.. (1397). Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin. , 29(2), 121-127. doi: 10.22059/jsciences.2018.65018
B. Heidary Alizadeh; Gh. Dehghan; V. Derakhsh Ahmadi; S. Moghimi; A. Asadipour; A. Foroumadi. "Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin". , 29, 2, 1397, 121-127. doi: 10.22059/jsciences.2018.65018
Heidary Alizadeh, B., Dehghan, Gh., Derakhsh Ahmadi, V., Moghimi, S., Asadipour, A., Foroumadi, A.. (1397). 'Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin', , 29(2), pp. 121-127. doi: 10.22059/jsciences.2018.65018
Heidary Alizadeh, B., Dehghan, Gh., Derakhsh Ahmadi, V., Moghimi, S., Asadipour, A., Foroumadi, A.. Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin. , 1397; 29(2): 121-127. doi: 10.22059/jsciences.2018.65018

Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin

Journal of Sciences, Islamic Republic of Iran
مقاله 3، دوره 29، شماره 2، تیر 2018، صفحه 121-127    اصل مقاله (230.11 K)
نوع مقاله: Final File
شناسه دیجیتال (DOI): 10.22059/jsciences.2018.65018
نویسندگان
B. Heidary Alizadeh1؛ Gh. Dehghan2؛ V. Derakhsh Ahmadi3؛ S. Moghimi4؛ A. Asadipour5؛ A. Foroumadi* 6
1Iranian Research Institute of Plant Protection (IRIPP), Tehran, Islamic Republic of Iran
22 Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Islamic Republic of Iran
33 Department of Pesticides, Iranian Research Institute of Plant Protection, Arak, Islamic Republic of Iran
44 Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
55 Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran
66 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
چکیده
The binding interaction of novel podophyllotoxin derivative, (3R,4R)-4-((benzo[d][1,3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3,4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UV-Visible absorption spectrophotometry, fluorescence spectroscopy, viscosity measurement and molecular docking studies. UV-Vis absorption results showed hyperchromic effect and low binding constant value (1.01×104 M-1), indicating non-intercalative interaction as a binding mode. The competitive fluorescence study also confirmed the obtained results from UV-Vis absorption spectra. Small changes in the viscosity of DNA exhibited that the interaction of PPT with DNA is based on groove binding mode. Molecular docking study showed minor groove interaction and -7.08 kcal/mol as a calculated energy.
 
کلیدواژه‌ها
Spectroscopy؛ Podophyllotoxin؛ DNA؛ Ccompetitive fluorescence؛ Groove binding
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