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Salihi, Abbas, Shekha, Mudhir, Al-Habib, Omar. (1395). Vasodilatory effects of nitric oxide, hydrogen sulfide and sulfur dioxide in rats: Time-dependent interaction study. , 6(1), 19-30. doi: 10.22059/pbs.2016.59004
Abbas B.Q. Salihi; Mudhir S. Shekha; Omar A.M. Al-Habib. "Vasodilatory effects of nitric oxide, hydrogen sulfide and sulfur dioxide in rats: Time-dependent interaction study". , 6, 1, 1395, 19-30. doi: 10.22059/pbs.2016.59004
Salihi, Abbas, Shekha, Mudhir, Al-Habib, Omar. (1395). 'Vasodilatory effects of nitric oxide, hydrogen sulfide and sulfur dioxide in rats: Time-dependent interaction study', , 6(1), pp. 19-30. doi: 10.22059/pbs.2016.59004
Salihi, Abbas, Shekha, Mudhir, Al-Habib, Omar. Vasodilatory effects of nitric oxide, hydrogen sulfide and sulfur dioxide in rats: Time-dependent interaction study. , 1395; 6(1): 19-30. doi: 10.22059/pbs.2016.59004

Vasodilatory effects of nitric oxide, hydrogen sulfide and sulfur dioxide in rats: Time-dependent interaction study

Progress in Biological Sciences
مقاله 3، دوره 6، شماره 1، شهریور 2016، صفحه 19-30    اصل مقاله (771.49 K)
نوع مقاله: Original Research Papers
شناسه دیجیتال (DOI): 10.22059/pbs.2016.59004
نویسندگان
Abbas B.Q. Salihi* 1؛ Mudhir S. Shekha2؛ Omar A.M. Al-Habib3
1Department of Biology, College of Science, Salahaddin University-Erbil
2Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq
3Department of Biology, Faculty of Science, University of Zakho, Duhok, Kurdistan region, Iraq
چکیده
The vasodilator response of nitric oxide (NO), hydrogen sulfide (H2S) and sulfur dioxide (SO2) were studied to
determine the significance of the actions and interactions of these gasotransmitters for controlling aortic tone in rats. The isometric tension of five separate sets of experiments was recorded. Sodium nitroprusside (SNP; NO donor), sodium disulphide (Na2S; H2S donor), SO2 derivatives and their paired combinations were added to phenylephrine (PE)-induced contraction during the peak value. Then maximal relaxation rate was calculated four times at 5 min intervals. Tetraethylammonium (TEA) and Glibenclamide (GLIB) were applied for investigating the molecular mechanism of the gasses. While, in a separate set of experiments, we used either L-Arginine (L-Arg), L-Cysteine (L-Cyst) or L-nitroarginine methyl ester (L-NAME) before applying gasotransmitters. Highest and prolonged relaxation rate were recorded when SNP was combined with SO2. The combination of Na2S and SO2-induced vasorelaxation was blocked by TEA and GLIB pretreatments. L-Cyst decreased relaxation compared to SNP and vice versa to SO2 induced vasorelaxation. L-Arg markedly attenuated relaxation responses of Na2S and SO2 derivatives. Also, L-NAME delayed relaxation compared to Na2S and SO2. These results suggest that exogenous paired combinations of H2S, NO and SO2 will enhance and elongate the rate of aortic relaxation. Meanwhile, preincubation of aortic rings with precursors attenuate the dilatory effects of exogenous studied gases.
کلیدواژه‌ها
Gasotransmitters؛ nitric oxide؛ Hydrogen Sulfide؛ Sulfur Dioxide؛ Vasotion
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