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Akbarzadeh, T., Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Parang, K., Foroumadi, A.. (1394). Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors. , 26(4), 321-325.
T. Akbarzadeh; A. Rafinejad; A. Fallah-Tafti; R. Tiwari; A. Nasrolahi Shirazi; D. Mandal; K. Parang; A. Foroumadi. "Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors". , 26, 4, 1394, 321-325.
Akbarzadeh, T., Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Parang, K., Foroumadi, A.. (1394). 'Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors', , 26(4), pp. 321-325.
Akbarzadeh, T., Rafinejad, A., Fallah-Tafti, A., Tiwari, R., Nasrolahi Shirazi, A., Mandal, D., Parang, K., Foroumadi, A.. Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors. , 1394; 26(4): 321-325.

Synthesis and Evaluation of Ethyl 2,4-dioxo-4-arylbutanoate Derivatives as Src Kinase Inhibitors

Journal of Sciences, Islamic Republic of Iran
مقاله 3، دوره 26، شماره 4، اسفند 2015، صفحه 321-325    اصل مقاله (385.74 K)
نوع مقاله: Final File
نویسندگان
T. Akbarzadeh* 1؛ A. Rafinejad1؛ A. Fallah-Tafti1؛ R. Tiwari2؛ A. Nasrolahi Shirazi2؛ D. Mandal2؛ K. Parang2؛ A. Foroumadi3
11 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
22 Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
33 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
چکیده
In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug. 
کلیدواژه‌ها
Ethyl 2,4-dioxo-4-arylbutanoates؛ Src kinase؛ cancer
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