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In vitro antifungal activity of Zataria multiflora essential oil, fluconazole and ciclopirox olamine against nonalbicans Candida species isolated from recurrent vulvovaginal candidiasis | ||
Journal of Mycology Research | ||
مقاله 2، دوره 2، شماره 1، خرداد 2015، صفحه 3-8 اصل مقاله (350.88 K) | ||
نوع مقاله: Original Articles | ||
نویسندگان | ||
Mohammad Ali Esfandiary1؛ Shahram Mahmoudi1؛ Farideh Zaini1؛ Mahin Safara1؛ Mahmoud Mahmoudi2؛ Alireza Farasat3؛ Azar Sabokbar4؛ Sanaz Abbasi4؛ Mohammad Ghahri5؛ Mohammad Amin Esfandiary6؛ Parivash Kordbacheh* 7 | ||
1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran | ||
2Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. | ||
3Young Researchers & Elite Club, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran | ||
4Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran. | ||
5Department of Biological Sciences, College of Sciences, Imam Hussein University, Tehran, Iran. | ||
6Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran. | ||
7Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. | ||
چکیده | ||
The aim of the present study was to investigate the antifungal activity of Zataria multiflora essential oil, fluconazole and ciclopirox olamine against 44 non-albicans Candida isolates from patients with recurrent vulvovaginal candidiasis. A set of C. glabrata (29 strains), C. krusei (3 stains) and C. patapsilosis (2 strains) were studied using Clinical and Laboratory Standards Institute (CLSI) broth macrodilution method. The results revealed that 33 isolates were resistant (MIC=64 μg/ml), 4 isolates were susceptible (MIC≤ 8 μg/ml) and 7 isolates had dose-dependent susceptibility (MIC= 16, 32 μg/ml) to fluconazole, respectively. With regard to fluconazole, high resistance rate was observed in C .glabrata and C. krusei. However, ciclopirox olamine was found to inhibit the growth of all non-albicans Candida species (MIC≤8 μg/ml). In this study, favorable antifungal activity against non-albicans Candida species was obtained by Z. multiflora despite having a wide range of MICs (34875-139500 μg/ml). The results indicated that ciclopirox olamine and Z. multiflora might be promising in the treatment of recurrent vulvovaginal candidiasis. | ||
کلیدواژهها | ||
ciclopirox olamine؛ fluconazole؛ non-albicans candida spp؛ recurrent vulvovaginal candidiasis؛ Zataria multiflora | ||
مراجع | ||
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