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Purification and Characterization of an Antibacterial, Antifungal and Non Hemolytic Peptide from Rana Ridibunda | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 1، دوره 15، شماره 4، اسفند 2004 اصل مقاله (338.26 K) | ||
| چکیده | ||
| Amphibians have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. A novel peptide with antibacterial effects and without hemolytic activity was purified from skin secretions of Rana ridibunda by multisteps cation-exchange FPLC, reversed-phase HPLC and was called Ridibundin 1. Circular dichroism spectra revealed that this peptide strongly prefers to form an amphipathic ?-helical structure in the presence of 50% trifluoroethanol. Acting as wide-spectrum microbicides against a variety of bacteria, Ridibundin 1 also shows no hemolytic activity on erythrocyte. These properties reveal its unique characteristics and potential therapeutic application | ||
| عنوان مقاله [English] | ||
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| چکیده [English] | ||
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آمار تعداد مشاهده مقاله: 1,138 تعداد دریافت فایل اصل مقاله: 1,752 |
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