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STUDIES ON HYDRALAZINES - PART-1x1 PREPARATION AND ANTIMICROBIAL ACTIVITY OF 1 - (PHTHALAZIN- 1 '-YLAMINO)- 3-CHLORO-4-ARYL- 4H-(OR 4-METHYL)-2-AZETIDINONE | ||
Journal of Sciences, Islamic Republic of Iran | ||
مقاله 7، دوره 2، شماره 2، اسفند 1991 اصل مقاله (246.61 K) | ||
چکیده | ||
1- (Phthalazin-l'-yl-amino)-3-chloro-4-aryl-4H-(4o-rm ethyl)-2-azetidinones (3) were prepared by cycloaddition of-methyl substituted benzal hydrazinophthalazine (2) with chloro acetylchloride. The hydrazone (2) was synthesised by the condensation of 1- hydrazinophthalazine (1) with substituted aromatic aldehydes, ketones 7 acetophenones. 1- Hydrazinophthalazine was prepared from the phthalaldehydic acid. All the compounds thus synthesised (2 and 3) were tested against different species of bacterial and fungi. Their structures have been ktermined by NMR and Mass spectroscopy | ||
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چکیده [English] | ||
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