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. (1372). SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES. , 4(2), -.
. "SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES". , 4, 2, 1372, -.
. (1372). 'SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES', , 4(2), pp. -.
. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES. , 1372; 4(2): -.

SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES

Journal of Sciences, Islamic Republic of Iran
مقاله 8، دوره 4، شماره 2، شهریور 1993    اصل مقاله (765.31 K)
چکیده
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2-
arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3
yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl
(or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2-
pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l-methyl-5-
nitroimidazole-2-carboxaldehyde (7) with 6 in ethanol afforded compound 8 in good
yield. The antibacterial and antifungal activities of compounds 5,6 and 8 were
determined
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