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. (1376). SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES. , 9(1), -.
. "SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES". , 9, 1, 1376, -.
. (1376). 'SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES', , 9(1), pp. -.
. SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES. , 1376; 9(1): -.

SYNTHESES, ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED 1,2, CTRIMOLES

Journal of Sciences, Islamic Republic of Iran
مقاله 7، دوره 9، شماره 1، خرداد 1998    اصل مقاله (239.83 K)
چکیده
The reaction of readily available 1 -methyl-4-nitropyrrole-2- carboxylic acid (1)
with thionyl chloride afforded the corresponding acyl chloride 2. The reaction of
compound 2 with thiosemicarbazides yielded 1-(1 -methyl-4-nitrop yrrole-2-carbony1)-
thiosemicarbazides (3) which cyclized in basic medium to 5-(1-methyl-4-nitropyrrole-
2-y1)-2,4-dihydro-3H- l,2,4-triazole-3- thione 4. Alkylation and subsequent oxidation
of 4 gave 6. The antibacterial and antifungal activities of 6a to 6f against a number
of microorganisms were determined. Only compounds 6b and 6c had moderate
activity against Aspergilus niger
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