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Preliminary data suggest possible association between IL-32 expression level and time of MS attack | ||
Progress in Biological Sciences | ||
مقاله 6، دوره 1، شماره 2، دی 2011، صفحه 44-49 اصل مقاله (269.9 K) | ||
شناسه دیجیتال (DOI): 10.22059/pbs.2011.24289 | ||
نویسندگان | ||
Mehrzad Roghani1؛ Fereidoun Mahboudi2؛ Mohammad Ali Sahraian3؛ Masoud Etemadifar4؛ Elahe Elahi5 | ||
1PHD.University of Tehran | ||
2PHD.Pasteur Institute of Iran | ||
3PHD.Tehran University of Medical Sciences | ||
4PHD.Isfahan University of Medical Sciences | ||
5PHD.of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran | ||
چکیده | ||
IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49. | ||
کلیدواژهها | ||
mRNA؛ patients؛ preliminary؛ TNFα | ||
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