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Roghani, Mehrzad, Mahboudi, Fereidoun, Sahraian, Mohammad Ali, Etemadifar, Masoud, Elahi, Elahe. (1390). Preliminary data suggest possible association between IL-32 expression level and time of MS attack. , 1(2), 44-49. doi: 10.22059/pbs.2011.24289
Mehrzad Roghani; Fereidoun Mahboudi; Mohammad Ali Sahraian; Masoud Etemadifar; Elahe Elahi. "Preliminary data suggest possible association between IL-32 expression level and time of MS attack". , 1, 2, 1390, 44-49. doi: 10.22059/pbs.2011.24289
Roghani, Mehrzad, Mahboudi, Fereidoun, Sahraian, Mohammad Ali, Etemadifar, Masoud, Elahi, Elahe. (1390). 'Preliminary data suggest possible association between IL-32 expression level and time of MS attack', , 1(2), pp. 44-49. doi: 10.22059/pbs.2011.24289
Roghani, Mehrzad, Mahboudi, Fereidoun, Sahraian, Mohammad Ali, Etemadifar, Masoud, Elahi, Elahe. Preliminary data suggest possible association between IL-32 expression level and time of MS attack. , 1390; 1(2): 44-49. doi: 10.22059/pbs.2011.24289

Preliminary data suggest possible association between IL-32 expression level and time of MS attack

Progress in Biological Sciences
مقاله 6، دوره 1، شماره 2، دی 2011، صفحه 44-49    اصل مقاله (269.9 K)
شناسه دیجیتال (DOI): 10.22059/pbs.2011.24289
نویسندگان
Mehrzad Roghani1؛ Fereidoun Mahboudi2؛ Mohammad Ali Sahraian3؛ Masoud Etemadifar4؛ Elahe Elahi5
1PHD.University of Tehran
2PHD.Pasteur Institute of Iran
3PHD.Tehran University of Medical Sciences
4PHD.Isfahan University of Medical Sciences
5PHD.of Mathematics, Statistics and Computer Science, College of Science, University of Tehran, Tehran, Iran
چکیده
IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49.
کلیدواژه‌ها
mRNA؛ patients؛ preliminary؛ TNFα
عنوان مقاله [English]
Preliminary data suggest possible association between IL-32 expression level and time of MS attack
نویسندگان [English]
Mehrzad Roghani1؛ Fereidoun Mahboudi2؛ Mohammad Ali Sahraian3؛ Masoud Etemadifar4؛ Elahe Elahi5
چکیده [English]
IL-32 and TNF? are important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNF? transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference in IL-32 and TNF? mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels of IL-32 mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features..? 2011 Progress in Biological Sciences. Vol. 1, No. 2, 44-49.
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