پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 161 |
| تعداد شماره‌ها | 6,532 |
| تعداد مقالات | 70,501 |
| تعداد مشاهده مقاله | 124,099,030 |
| تعداد دریافت فایل اصل مقاله | 97,206,585 |
The pretreatment effects of pentoxifylline on aflatoxin B1-induced oxidative damage in perfused rat liver | ||
| Iranian Journal of Veterinary Medicine | ||
| مقاله 9، دوره 5، شماره 1 - شماره پیاپی 498114، خرداد 2011، صفحه 43-47 اصل مقاله (121.89 K) | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2011.22670 | ||
| نویسندگان | ||
| محمد کاظم کوهی1؛ Ebrahim Shahroziyan1؛ Mahmood Ghazi khansari2؛ Bahram Daraei3؛ Abbas Javaheri4؛ Amir Moghadam jafari1؛ Goodarz Sadeghi Hashjin1 | ||
| 1دانشکده دامپزشکی دانشگاه تهران | ||
| 2دانشگاه علوم پزشکی تهران | ||
| 3دانشکده پزشکی دانشگاه تربیت مدرس | ||
| 4دانشکده دامپزشکی دانشگاه سمنان | ||
| چکیده | ||
| This study was conducted to investigate the hepatoprotective and antioxidant effects of pentoxifylline (PTX) against aflatoxin B1 (AFB1) exposure in perfused rat livers by evaluating damage marker enzymes, antioxidant defense systems (glutathione, GSH) and lipid peroxidation (malondialdehyde, MDA). Sixteen rats were divided randomly into four experimental groups: control, PTX, AFB1 and AFB1 + PTX. Rats in the control group were infused with Krebs–Henseleit bicarbonate buffer. Rats in the AFB1-treated group received approximately 1 ppm and the PTX- treated group received 100 mg/kg intraperitoneally 24 h before surgery. Alanine aminotransferase and lactate dehydrogenase levels were increased by AFB1 and decreased by PTX. PTX also ameliorated the increased concentration of MDA caused by AFB1. PTX did not compensate for the decrease in GSH caused by AFB1. These results imply that PTX has an antioxidant effect by inhibiting free radicals, and prior treatment with PTX ameliorates the effects of AFB1-induced lipid peroxidation but does not compensate GSH depots. | ||
|
آمار تعداد مشاهده مقاله: 2,045 تعداد دریافت فایل اصل مقاله: 2,136 |
||