سامانه پشتیبانی خدمات اطلاعات

  اخبار و اعلانات

 آمار

تعداد نشریات161
تعداد شماره‌ها6,573
تعداد مقالات71,037
تعداد مشاهده مقاله125,524,652
تعداد دریافت فایل اصل مقاله98,785,303
Koohi, Mohammad Kazem, Zare Mirakabadi, Abbas, Moharrami, Mojtaba, Hablolvarid, Mohammad Hassan. (1388). Anti-cancer effect of ICD-85(venom derived peptides) on MDA-MB231 cell line (in vitro) and experimental mice with breast cancer (in vivo). , 3(1), -. doi: 10.22059/ijvm.2009.19609
Mohammad Kazem Koohi; Abbas Zare Mirakabadi; Mojtaba Moharrami; Mohammad Hassan Hablolvarid. "Anti-cancer effect of ICD-85(venom derived peptides) on MDA-MB231 cell line (in vitro) and experimental mice with breast cancer (in vivo)". , 3, 1, 1388, -. doi: 10.22059/ijvm.2009.19609
Koohi, Mohammad Kazem, Zare Mirakabadi, Abbas, Moharrami, Mojtaba, Hablolvarid, Mohammad Hassan. (1388). 'Anti-cancer effect of ICD-85(venom derived peptides) on MDA-MB231 cell line (in vitro) and experimental mice with breast cancer (in vivo)', , 3(1), pp. -. doi: 10.22059/ijvm.2009.19609
Koohi, Mohammad Kazem, Zare Mirakabadi, Abbas, Moharrami, Mojtaba, Hablolvarid, Mohammad Hassan. Anti-cancer effect of ICD-85(venom derived peptides) on MDA-MB231 cell line (in vitro) and experimental mice with breast cancer (in vivo). , 1388; 3(1): -. doi: 10.22059/ijvm.2009.19609

Anti-cancer effect of ICD-85(venom derived peptides) on MDA-MB231 cell line (in vitro) and experimental mice with breast cancer (in vivo)

Iranian Journal of Veterinary Medicine
مقاله 8، دوره 3، شماره 1، مهر 2009    اصل مقاله (415.71 K)
شناسه دیجیتال (DOI): 10.22059/ijvm.2009.19609
نویسندگان
Mohammad Kazem Koohi1؛ Abbas Zare Mirakabadi2؛ Mojtaba Moharrami2؛ Mohammad Hassan Hablolvarid1
1دانشکده دامپزشکی
2موسسه تحقیقات واکسن رازی
چکیده
Breast cancer has become common in developing and developed countries. Alarming increase in this disease as a leading cause of death in women is a concern of all. Despite the significant improvements in the management of breast cancer, the survival rate is not more than 20% - 25%. For this study, MDA-MB231 cell line was used and the effect of ICD-85 (biologically active peptides from venomous animals) was assayed by measuring the activity of the cytosolic enzyme lactate dehydrogenase(LDH) released into the culture medium after membrane legions. Morphological changes of cells were checked in control and cells incubated with ICD-85 as chemo preventive agent. Results showing in test groups - incubation with 10mg/ml dose of ICD-85 had decreased cytoplasmic branch. Some cells were ruptured and lost the continuity of their surrounding membranes, and number of cells was decreased. On the other hand, when ICD-85 was used as an anticancer treatment of mice with breast cancer, it was shown that ICD-85 can prevent the growth of breast tumor, increase the life duration of experimental mice and inhibit angiogenesis in breast tumor as compared with control group. It seems that ICD-85 acts at the membrane level and can prevent the cell growth as well as producing apoptosis (cell suicide) for breast cancer cells.
کلیدواژه‌ها
85ICD-‌
آمار
تعداد مشاهده مقاله: 1,701
تعداد دریافت فایل اصل مقاله: 2,354





سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب