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Synergistic Role of Lactoferrin and Probiotics in Improving Intestinal Barrier Integrity Under Heat Stress Conditions in Broilers | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 خرداد 1405 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2026.412827.1006067 | ||
| نویسندگان | ||
| Mohammed Ali Hameed Najafi* ؛ Sawsan Kadhim Mashi | ||
| Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq | ||
| چکیده | ||
| Abstract Heat stress is a major environmental challenge that adversely affects poultry production by impairing intestinal barrier integrity, inducing oxidative stress, and reducing growth performance. It disrupts epithelial morphology and tight junction organization, leading to increased intestinal permeability and physiological imbalance. Objective: This study aimed to evaluate the synergistic effects of lactoferrin, alone or in combination with probiotics, on intestinal barrier integrity, histomorphological changes, physiological stress responses, antioxidant status, and growth performance in heat-stressed broiler chickens. Methods: Eighty one-day-old Ross 308 broiler chicks were randomly assigned to four groups (n = 20): control (thermoneutral), heat-stressed (36 ± 1 °C, days 7–14), lactoferrin-treated (250 mg/kg feed, days 14–21), and lactoferrin plus probiotics–treated (250 mg/kg lactoferrin and 5 × 10¹² CFU/kg feed, days 14–21). ZO-1 gene expression was assessed by quantitative real-time PCR. Intestinal morphology was examined histologically, while physiological stress markers (respiratory rate, rectal temperature, HSP70), total antioxidant capacity (TAC), and growth performance parameters were also evaluated. Results: Heat stress significantly reduced ZO-1 expression, disrupted intestinal morphology, increased physiological stress markers, and decreased antioxidant capacity (p < 0.05). Lactoferrin supplementation improved intestinal structure, enhanced ZO-1 expression, and partially restored antioxidant status. The combined treatment produced greater improvements, restoring intestinal architecture, reducing stress indicators, and improving growth performance compared with lactoferrin alone (p < 0.05). Conclusion: Lactoferrin, particularly in combination with probiotics, effectively mitigates heat stress–induced intestinal dysfunction and improves physiological and productive performance in broiler chickens, highlighting its potential as a practical nutritional strategy under heat stress conditions. | ||
| کلیدواژهها | ||
| Broiler chickens؛ Heat stress؛ Intestinal barrier؛ Lactoferrin؛ Probiotics | ||
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آمار تعداد مشاهده مقاله: 11 |
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