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Hassanpour hosseinabadi, fatemeh, irandoust, khadijeh, Taheri, Morteza, Shaabani Ezdini, Ebrahim. (1405). Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats: An Experimental Study. , (), -. doi: 10.22059/sshr.2025.398024.1201
fatemeh Hassanpour hosseinabadi; khadijeh irandoust; Morteza Taheri; Ebrahim Shaabani Ezdini. "Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats: An Experimental Study". , , , 1405, -. doi: 10.22059/sshr.2025.398024.1201
Hassanpour hosseinabadi, fatemeh, irandoust, khadijeh, Taheri, Morteza, Shaabani Ezdini, Ebrahim. (1405). 'Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats: An Experimental Study', , (), pp. -. doi: 10.22059/sshr.2025.398024.1201
Hassanpour hosseinabadi, fatemeh, irandoust, khadijeh, Taheri, Morteza, Shaabani Ezdini, Ebrahim. Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats: An Experimental Study. , 1405; (): -. doi: 10.22059/sshr.2025.398024.1201

Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats: An Experimental Study

Sport Sciences and Health Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 17 خرداد 1405
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/sshr.2025.398024.1201
نویسندگان
fatemeh Hassanpour hosseinabadi1؛ khadijeh irandoust* 2؛ Morteza Taheri3؛ Ebrahim Shaabani Ezdini4
1Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin
2Associate Professor, Imam Khomeini International University
3Department of Behavioral and Cognitive Sciences in Sport, Faculty of Sport Sciences and Health. University of Tehran, Iran
4Department of Sports Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
چکیده
background: Type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications.
Aim: Effects of Aerobic Exercise and Chia on Bax/Bcl-2 Ratio in Hearts of Type 2 Diabetic Rats.
Materials and Methods: 50 male diabetic Wistar rats were randomly assigned to five groups: healthy control (HC), diabetic control (DC), diabetic chia supplementation (DCS), diabetic exercise (DE), and diabetic exercise-chia supplementation (DECS). The exercise program lasted for eight weeks. Chia supplementation was available for groups. apoptosis was measured using the RT-PCR methods. Statistical analysis was performed using two-way ANOVA and Tukey’s post hoc test.
Results: The Bax/β-actin ratio was significantly lower in the DECS group (0.74 ± 0.26) compared to the DC group (1.84 ± 0.63; p = 0.01). No significant changes were observed in Bcl-2 expression across groups (p ≥ 0.05). The Bax/Bcl-2 ratio was markedly reduced in both the DE (1.56 ± 0.62) and DECS (0.96 ± 0.42) groups compared to the DC group (2.57 ± 0.71; p = 0.02 and p = 0.00, respectively), with the greatest reduction observed in the combined intervention group.
Conclusion: aerobic exercise and chia supplementation reduced cardiac Bax expression and the Bax/Bcl-2 ratio in type 2 diabetic rats, however, Cardioprotection requires functional cardiac outcomes.
کلیدواژه‌ها
ontinuous aerobic exercise؛ chia consumption؛ Bax؛ Bcl-2؛ Diabetes
آمار
تعداد مشاهده مقاله: 21





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