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Pro- and Antioxidant Profile Markers in Follicular Fluid of Mares | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 29 اردیبهشت 1405 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2026.406039.1005966 | ||
| نویسندگان | ||
| Olga Bakovetskaya* 1؛ Lyudmila Fedorovna Lebedeva2؛ Elena Vladimirovna Solodova2؛ Yulia Vladimirovna Abalenikhina3؛ Alexey Vladimirovich Shchulkin4؛ Svetlana Sergeevna Balashova5؛ Anna Alexandrovna Terekhina5 | ||
| 1Department of Biology, Faculty of Medicine and Prevention, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia | ||
| 2Laboratory of physiology, The All-Russian Research Institute for Horse Breeding Ryazan Region, Rybnovsky District, Divovo, Russian Federation | ||
| 3Departments of Biochemistry, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, 390026, Russian Federation | ||
| 4Departments of Biology and Biochemistry, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation | ||
| 5Departments of Biology, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation | ||
| چکیده | ||
| Abstract Background: Comprehensive characterization of the oocyte microenvironment in follicles is important for improving ART in horses. Objectives: The aim of the pilot study was to investigate possible pro- and antioxidant markers of mares’ follicular fluid (FF) in connection with follicle development stage and functional status. Methods: FF was obtained by the Ovum PickUp method in the transitional (anovulatory) (TP) and breeding ovulatory (OP) periods. 7 indicators of pro- and antioxidant factors (thiobarbituric acid (TBA-reactive products), superoxide dismutase (SOD), the TBA/SOD ratio, carbonyl derivatives of proteins, glutathione peroxidase (GPx), non-protein and protein SH groups) were examined. Results: Signs of oxidative stress (OS) were revealed in medium (22-30 mm, TP) and large (≥35 mm, OP) follicles (P<0,01), which corresponded to the stages of follicles deviation and late maturation. Activation of the antioxidant system was observed in large (≥31 mm) follicles, both with and without signs of luteinization, during TP and in hormonally stimulated preovulatory follicles (OP) (P<0,05). Conclusions: It can be assumed that OS being a trigger for deviation and ovulation. The observed trend toward the predominance of antioxidant protection and the absence of OS in large and luteinizing follicles in TP may likely lead to follicles luteinization without ovulation. ROC analysis confirmed that TBA-reactive products and SOD could be the specific markers of the folliculogenesis process. Further research is needed to confirm the results of this pilot study. | ||
| کلیدواژهها | ||
| mares؛ follicular fluid؛ estrus cycle؛ antioxidant profile؛ oxidative stress | ||
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آمار تعداد مشاهده مقاله: 35 |
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