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Rahimi, Mohammad Rahman, Faraji, Hassan, Kamangar, Sasan. (1404). The Effect of Exercise Training on the Levels of Anti-Inflammatory Factors (IL-4 and IL-10): A Meta-Analysis Study. , 17(2), 30-49. doi: 10.22059/sshr.2025.388153.1178
Mohammad Rahman Rahimi; Hassan Faraji; Sasan Kamangar. "The Effect of Exercise Training on the Levels of Anti-Inflammatory Factors (IL-4 and IL-10): A Meta-Analysis Study". , 17, 2, 1404, 30-49. doi: 10.22059/sshr.2025.388153.1178
Rahimi, Mohammad Rahman, Faraji, Hassan, Kamangar, Sasan. (1404). 'The Effect of Exercise Training on the Levels of Anti-Inflammatory Factors (IL-4 and IL-10): A Meta-Analysis Study', , 17(2), pp. 30-49. doi: 10.22059/sshr.2025.388153.1178
Rahimi, Mohammad Rahman, Faraji, Hassan, Kamangar, Sasan. The Effect of Exercise Training on the Levels of Anti-Inflammatory Factors (IL-4 and IL-10): A Meta-Analysis Study. , 1404; 17(2): 30-49. doi: 10.22059/sshr.2025.388153.1178

The Effect of Exercise Training on the Levels of Anti-Inflammatory Factors (IL-4 and IL-10): A Meta-Analysis Study

Sport Sciences and Health Research
دوره 17، شماره 2، مهر 2025، صفحه 30-49    اصل مقاله (1.32 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22059/sshr.2025.388153.1178
نویسندگان
Mohammad Rahman Rahimi* 1؛ Hassan Faraji2؛ Sasan Kamangar3
1Department of Exercise Physiology, University of Kurdistan, Sanandaj 66177-15175, Iran. ORCID No: https://orcid.org/0000-0002-4302-1472
2Department of Physical Education and Sport Sciences, Islamic Azad University, Marivan Branch, Marivan, Iran.
3Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran.
چکیده
Background: Anti-inflammatory markers play a crucial role in chronic diseases.. Regular training is a valuable method to control inflammation.
Aim: This meta-analysis aims to explore the impact of exercise training on anti-inflammatory indicators like IL-10 and IL-4.
Martials and methods: Various databases, including PubMed, Cochrane, Embase, Web of Science, EBSCO, and Google Scholar, were systematically searched for randomized controlled trials from 2007 to 2023. Studies focusing on IL-10 and IL-4 indicators in individuals undergoing exercise training were selected. According to the study inclusion criteria, ultimately, 40 articles were finally selected as study samples for the meta-analysis. The meta-analysis was conducted using fixed and random effects models to analyze the effect sizes, taking into account factors such as age, gender, health status, type and duration of exercise, and BM..
Results: Aerobic training significantly increased IL-10 levels (p=0.00, 95% CI=0.267:0.723, ES=0.495), while the increase after resistance training was not significant (ES=0.295, 95% CI-0.020:0.610, p=0.067). Both aerobic training (ES=-282, 95% CI=-0.795:0.185, p=0.237) and resistance training (ES=0.227, 95% CI=-0.389:0.843, p=0.471) had no significant effect onIL-4 levels. Subgroup analysis revealed a significant increase in IL-10 associated withBMI subgroups (p=0.019), with the highest increase in BMI group 18 to 25 (p=0.001). Subgroup meta-analysis for IL-4 showed no significant differences between subgroups (p>0.05).
Conclusion: Aerobic training was associated with a significant increase in IL-10 levels in healthy and unhealthy subjects, but aerobic and resistance training had no significant effect on IL-4 levels. Further randomized controlled studies are essential, especially focusing on resistance training and different training scenarios.
کلیدواژه‌ها
Aerobic Training؛   Resistance Training؛   Interleukin-10؛   Interleukin-4؛ Systemic Inflammation
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