میز خدمت الکترونیک
دوره ویراستاری

  اخبار و اعلانات

 آمار

تعداد نشریات127
تعداد شماره‌ها7,140
تعداد مقالات76,849
تعداد مشاهده مقاله154,463,653
تعداد دریافت فایل اصل مقاله116,517,409
Montazeri, Maryam, Davar Panah, Mohammad Ali, Montazeri, Mohammad, Davoodi, Lotfollah. (1403). Antiretroviral Therapy Among HIV-Infected Pregnant Women on Their Offspring. , 36(1), 21-27. doi: 10.22059/jsciences.2025.364675.1007825
Maryam Montazeri; Mohammad Ali Davar Panah; Mohammad Montazeri; Lotfollah Davoodi. "Antiretroviral Therapy Among HIV-Infected Pregnant Women on Their Offspring". , 36, 1, 1403, 21-27. doi: 10.22059/jsciences.2025.364675.1007825
Montazeri, Maryam, Davar Panah, Mohammad Ali, Montazeri, Mohammad, Davoodi, Lotfollah. (1403). 'Antiretroviral Therapy Among HIV-Infected Pregnant Women on Their Offspring', , 36(1), pp. 21-27. doi: 10.22059/jsciences.2025.364675.1007825
Montazeri, Maryam, Davar Panah, Mohammad Ali, Montazeri, Mohammad, Davoodi, Lotfollah. Antiretroviral Therapy Among HIV-Infected Pregnant Women on Their Offspring. , 1403; 36(1): 21-27. doi: 10.22059/jsciences.2025.364675.1007825

Antiretroviral Therapy Among HIV-Infected Pregnant Women on Their Offspring

Journal of Sciences, Islamic Republic of Iran
دوره 36، شماره 1، فروردین 2025، صفحه 21-27    اصل مقاله (320.24 K)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2025.364675.1007825
نویسندگان
Maryam Montazeri1؛ Mohammad Ali Davar Panah2؛ Mohammad Montazeri3؛ Lotfollah Davoodi* 4
11 Razi Clinical Researches Development, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran
22 Department of Infectious and Tropical Diseases, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
33 Sarem Fertility and Infertility Research Center (SAFIR), Sarem Women's Hospital, Tehran, Islamic Republic of Iran
44 Department of Infectious Diseases, Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran
چکیده
The risk of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection is approximately 30%. However, antiretroviral drugs can reduce MTCT to less than 2%. This study was designed to determine the effect of antiretroviral therapy among HIV-infected women and its maternal and neonatal outcomes in Iran. The study is a retrospective analysis of mother-infant data from Shiraz, Southern Iran, between 2006 and 2012. HIV-infected pregnant women were divided into two groups of intervention (receiving treatment or chemoprophylaxis) and control (not receiving any treatment). Maternal and neonatal information were extracted and recorded. The data were entered into SPSS software and were analyzed. The mother-to-child transmission was 2.9% in the intervention group compared to 15.8% in the control group (OR=0.01, 95% CI: 0.002-0.125, p<0.0001). The infant HIV infection rate was significantly higher in male infants (OR=2.76, CI 95% 2.213-3.327), NVD delivery (OR=3.78, CI 95% 3.140-4.409), and breastfeeding (OR=26, CI 95% 7.87-85.90). Treatment intervention significantly reduces the HIV transmission from infected mothers to their infants. However, the rate of vertical transmission in Iran remains higher than those reported in developed countries despite treatment interventions, and additional preventive measures appear necessary.
کلیدواژه‌ها
Chemoprophylaxis؛ Treatment؛ Pregnancy؛ HIV؛ Mother-to-Child Transmission
مراجع
1.    World Health Organization.  Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants: towards universal access. 2010 [cited 30 January 2012]. http://whqlibdoc.who.int/publications/2010/9789241599818_eng.pdf].
2.    World Health Organization. Programmatic update: use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. 2012 [cited 6 June 2012]. http://www.who.int/hiv/PMTCT_update.pdf].
3.    Ciaranello AL, Perez F, Engelsmann B, Walensky RP, Mushavi A, Rusibamayila A, et al. Cost-effectiveness of World Health Organization 2010 guidelines for prevention of mother-to-child HIV transmission in Zimbabwe. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013;56(3):430-46.
4.    Cotton MF, Marais BJ, Andersson MI, Eley B, Rabie H, Slogrove AL, et al. Minimizing the risk of non-vertical, non-sexual HIV infection in children--beyond mother to child transmission. Journal of the International AIDS Society. 2012;15(2):17377.
5.    Ciaranello AL, Perez F, Maruva M, Chu J, Engelsmann B, Keatinge J, et al. WHO 2010 guidelines for prevention of mother-to-child HIV transmission in Zimbabwe: modeling clinical outcomes in infants and mothers. PloS one. 2011;6(6):e20224.
6.    Ladner J, Besson MH, Rodrigues M, Sams K, Audureau E, Saba J. Prevention of mother-to-child HIV transmission in resource-limited settings: assessment of 99 Viramune Donation Programmes in 34 countries, 2000-2011. BMC public health. 2013;13:470.
7.    Kaida A, Matthews LT, Kanters S, Kabakyenga J, Muzoora C, Mocello AR, et al. Incidence and predictors of pregnancy among a cohort of HIV-positive women initiating antiretroviral therapy in Mbarara, Uganda. PloS one. 2013;8(5):e63411.
8.    Gamell A, Letang E, Jullu B, Mwaigomole G, Nyamtema A, Hatz C, et al. Uptake of guidelines on prevention of mother-to-child transmission of HIV in rural Tanzania: time for change. Swiss medical weekly. 2013;143:w13775.
9.    Yu L, Li WY, Chen RY, Tang ZR, Pang J, Gui XZ, et al. Pregnancy outcomes and risk factors for low birth weight and preterm delivery among HIV-infected pregnant women in Guangxi, China. Chinese medical journal. 2012;125(3):403-9.
10.    Anoje C, Aiyenigba B, Suzuki C, Badru T, Akpoigbe K, Odo M, et al. Reducing mother-to-child transmission of HIV: findings from an early infant diagnosis program in south-south region of Nigeria. BMC public health. 2012;12:184.
11.    Johnson LF, Stinson K, Newell ML, Bland RM, Moultrie H, Davies MA, et al. The contribution of maternal HIV seroconversion during late pregnancy and breastfeeding to mother-to-child transmission of HIV. Journal of acquired immune deficiency syndromes (1999). 2012;59(4):417-25.
12.    Whitmore SK, Taylor AW, Espinoza L, Shouse RL, Lampe MA, Nesheim S. Correlates of mother-to-child transmission of HIV in the United States and Puerto Rico. Pediatrics. 2012;129(1):e74-81.
13.    Merdekios B, Adedimeji AA. Effectiveness of interventions to prevent mother-to-child transmission of HIV in Southern Ethiopia. International journal of women's health. 2011;3:359-66.
14.    Cooper ER, Charurat M, Mofenson L, Hanson IC, Pitt J, Diaz C, et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. Journal of acquired immune deficiency syndromes (1999). 2002;29(5):484-94.
15.    Lim Y, Kim JY, Rich M, Stulac S, Niyonzima JB, Smith Fawzi MC, et al. Improving prevention of mother-to-child transmission of HIV care and related services in eastern Rwanda. PLoS medicine. 2010;7(7):e1000302.
16.    Sedaghat A, Gouya MM, Kamali K, Fahimfar N, Namdari Tabar H, Feiz zadeh A. Estimates the prevalence of HIV using model based design, 2010-2014. Science and Health journal. 2011;5(2):40.
17.    WEBDA news agency. Last reported AIDS cases registered in Iran until March of 2013.  [cited 28 April 2013]. http://webda.behdasht.gov.ir/index.aspx?siteid=326&pageid=32628&newsview=86794].
18.    Lussiana C, Clemente SV, Ghelardi A, Lonardi M, Pulido Tarquino IA, Floridia M. Effectiveness of a prevention of mother-to-child HIV transmission programme in an urban hospital in Angola. PloS one. 2012;7(4):e36381.
19.    Chetty T, Knight S, Giddy J, Crankshaw TL, Butler LM, Newell ML. A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa. BMC pediatrics. 2012;12:146.
20.    Goswami S, Chakravorty PS. Prevention of Parent to Child Transmission of HIV (PPTCT): An Effort of 4 Years in a Tertiary Centre. Journal of obstetrics and gynaecology of India. 2011;61(4):394-8.
21.    Koye DN, Zeleke BM. Mother-to-child transmission of HIV and its predictors among HIV-exposed infants at a PMTCT clinic in northwest Ethiopia. BMC public health. 2013;13(1):398.
22.    Neubert J, Pfeffer M, Borkhardt A, Niehues T, Adams O, Bolten M, et al. Risk adapted transmission prophylaxis to prevent vertical HIV-1 transmission: effectiveness and safety of an abbreviated regimen of postnatal oral zidovudine. BMC pregnancy and childbirth. 2013;13:22.
23.    Soeiro CM, Miranda AE, Saraceni V, Lucena NO, Talhari S, Ferreira LC. Mother-to-child transmission of HIV infection in Manaus, State of Amazonas, Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 2011;44(5):537-41.
24.    Vieira AC, Miranda AE, Vargas PR, Maciel EL. HIV prevalence in pregnant women and vertical transmission in according to socioeconomic status, Southeastern Brazil. Revista de saude publica. 2011;45(4):644-51.
25.    Warszawski J, Tubiana R, Le Chenadec J, Blanche S, Teglas JP, Dollfus C, et al. Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS (London, England). 2008;22(2):289-99.
26.    Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey PA. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006. AIDS (London, England). 2008;22(8):973-81.

آمار
تعداد مشاهده مقاله: 85
تعداد دریافت فایل اصل مقاله: 75





سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب