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Ghaderi-Zefrehei, mostafa, Rafeie, Farjad, Alipour Tabrizi, Arash, Baratieh, Zohreh, Fotouhi, Seyyed Kamal, Smith, Jacqueline, Muhaghegh Dolatabady, Mustafa. (1403). Genetic Analysis of Y-STRs in Two Iranian Sub-Populations. , 36(1), 5-19. doi: 10.22059/jsciences.2025.386444.1007900
mostafa Ghaderi-Zefrehei; Farjad Rafeie; Arash Alipour Tabrizi; Zohreh Baratieh; Seyyed Kamal Fotouhi; Jacqueline Smith; Mustafa Muhaghegh Dolatabady. "Genetic Analysis of Y-STRs in Two Iranian Sub-Populations". , 36, 1, 1403, 5-19. doi: 10.22059/jsciences.2025.386444.1007900
Ghaderi-Zefrehei, mostafa, Rafeie, Farjad, Alipour Tabrizi, Arash, Baratieh, Zohreh, Fotouhi, Seyyed Kamal, Smith, Jacqueline, Muhaghegh Dolatabady, Mustafa. (1403). 'Genetic Analysis of Y-STRs in Two Iranian Sub-Populations', , 36(1), pp. 5-19. doi: 10.22059/jsciences.2025.386444.1007900
Ghaderi-Zefrehei, mostafa, Rafeie, Farjad, Alipour Tabrizi, Arash, Baratieh, Zohreh, Fotouhi, Seyyed Kamal, Smith, Jacqueline, Muhaghegh Dolatabady, Mustafa. Genetic Analysis of Y-STRs in Two Iranian Sub-Populations. , 1403; 36(1): 5-19. doi: 10.22059/jsciences.2025.386444.1007900

Genetic Analysis of Y-STRs in Two Iranian Sub-Populations

Journal of Sciences, Islamic Republic of Iran
دوره 36، شماره 1، فروردین 2025، صفحه 5-19    اصل مقاله (1.43 M)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2025.386444.1007900
نویسندگان
mostafa Ghaderi-Zefrehei1؛ Farjad Rafeie2؛ Arash Alipour Tabrizi3؛ Zohreh Baratieh4؛ Seyyed Kamal Fotouhi4؛ Jacqueline Smith5؛ Mustafa Muhaghegh Dolatabady* 1
11 Department of Animal Science, Faculty of Agricultural Sciences, Yasouj University, Yasouj, Islamic Republic of Iran
22 Department of Agricultural Biotechnology, Faculty of Agricultural Sciences, University of Guilan, Rasht, Islamic Republic of Iran
33 Molecular Genetics Department, Mashhad Forensic Medical Center, Mashhad, Islamic Republic of Iran
44 Forensic Medical Research Center, National Forensic Medical Organization, Tehran, Islamic Republic of Iran
55 The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK
چکیده
This study presents a comprehensive genetic analysis of 17 Y-chromosomal short tandem repeat (Y-STR) loci in two Iranian sub-populations from the Fars (n=109) and Isfahan (n=180) provinces. The loci investigated included DYS19, DYS385a/b, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 (Y-GATA-C4), and Y-GATA-H4. Results demonstrated that the DYS385a/b locus exhibited the greatest allelic diversity in both populations, with 11 distinct alleles detected and mean allele counts of 6.29 and 5.88 in the Fars and Isfahan groups, respectively. Conversely, the Fars cohort showed the lowest allelic variation (three alleles) at DYS439 and Y-GATA-H4 loci, while the Isfahan population exhibited minimal variation (four alleles) at DYS19 and DYS439. Haplotype analyses revealed intra-population sharing rates of 2.75% in Fars and 10.0% in Isfahan, with an overall 8.3% haplotype overlap observed across the combined dataset of 289 individuals. Both populations exhibited high haplotype diversity values approaching 0.99, indicating substantial genetic variability. The haplotype discrimination capacity varied among populations, with value of 0.9725 for Fars, 0.8519 for Isfahan, and 0.9170 for the entire sample set. Population differentiation was assessed using pairwise FST and RST metrics, which confirmed significant genetic divergence between Fars and Isfahan groups (FST = 0.00743, p < 0.001; RST = 0.0106, p < 0.01). These findings underscore the genetic distinctness of the two sub-populations. The study highlights the necessity for further research incorporating Y-chromosomal single-nucleotide polymorphisms (Y-SNPs), larger sample sizes, and additional ancestral information to enhance the understanding of genetic structure and demographic history within Iranian populations.
کلیدواژه‌ها
Haplotype؛ Genetic diversity؛ Y-STR markers
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