پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 127 |
| تعداد شمارهها | 7,196 |
| تعداد مقالات | 77,227 |
| تعداد مشاهده مقاله | 157,217,993 |
| تعداد دریافت فایل اصل مقاله | 118,403,668 |
Effects of Resveratrol on blood parameters of dexamethasone-induced hypercortisolism in a Rat Model | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 بهمن 1404 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2025.396006.1005815 | ||
| نویسندگان | ||
| Masumeh Rezaei1؛ shahin Hassanpour* 2؛ Ehsan Khaksar3 | ||
| 1Graduate student, Faculty of Veterinary Medicine, SR.C, Islamic Azad University, Tehran, Iran | ||
| 2Assistant Professor, department of Physiology Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University-Tehran-Iran | ||
| 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran | ||
| چکیده | ||
| BACKGROUND: Glucocorticoid-induced hypercortisolism, a common complication of prolonged dexamethasone use, disrupts metabolic and endocrine homeostasis. Current therapeutic strategies remain limited, necessitating novel interventions. Resveratrol, a polyphenol with anti-inflammatory and antioxidant properties, shows potential in modulating glucocorticoid signaling. This study investigates its efficacy in mitigating dexamethasone-induced hypercortisolism in a rat model. OBJECTIVES: of resveratrol on blood parameters in alleviating dexamethasone-induced hypercortisolism in Wistar rats. METHODS: Twenty-four male Wistar rats were obtained from the Pasteur Institute of Iran and randomly allocated to four groups: (1) untreated control; (2) hypercortisolism induction via oral dexamethasone (100 μg/kg) for 4 weeks; (3) co-administration of dexamethasone dexamethasone (100 μg/kg) and ketoconazole (5 mg/kg) for 4 weeks; and (4) co-administration of dexamethasone (100 μg/kg) and resveratrol (80 mg/kg) for 4 weeks. Serum biomarkers—cortisol, glucose, triglycerides, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), creatinine and total protein (TP) were then analyzed. RESULTS: Neither ketoconazole nor resveratrol significantly altered body weight in hypercortisolemic rats (P = 0.45). Dexamethasone and dexamethasone-ketoconazole administration elevated serum cortisol, whereas resveratrol attenuated serum cortisol levels (P = 0.022). Dexamethasone increased serum glucose, cholesterol, triglycerides, and LDL (P = 0.011), while reducing HDL (P = 0.014) and TP; resveratrol reversed the changes in these blood parameters (P = 0.027). CONCLUSIONS: These findings indicate that resveratrol attenuates the biochemical alterations associated with experimental hypercortisolism, underscoring its potential utility as a therapeutic agent in the management of hypercortisolism disorders. | ||
| کلیدواژهها | ||
| Hypercortisolism؛ Resveratrol؛ Rat؛ Dexamethasone؛ Biochemical parameters | ||
|
آمار تعداد مشاهده مقاله: 57 |
||
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب