اثر مکمل‌یاری عصارۀ برگ زیتون و تمرینات دایره‌ای با شدت بالا بر سطوح سرمی سالوسین آلفا و بتا و مقاومت به انسولین در زنان سالمند چاق

[1].Dunlop DD, Song J, Arntson EK, Semanik PA, Lee J, Chang RW, Hootman JM: Sedentary time in US older adults associated with disability in activities of daily living independent of physical activity. Journal of Physical activity and Health. 2015, 12(1):93-101.

[2].King AC, Guralnik JM: Maximizing the potential of an aging population. JAMA 2010, 304(17):1944-1945.

[3].Vaisi-Raygani A, Mohammadi M, Jalali R, Ghobadi A, Salari N: The prevalence of obesity in older adults in Iran: a systematic review and meta-analysis. BMC geriatrics. 2019, 19(1):1-9.

[4].Chang VW, Alley DE, Dowd JB: Trends in the relationship between obesity and disability, 1988–2012. American Journal of Epidemiology. 2017, 186(6):688-695.

[5].Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL: Fat tissue, aging, and cellular senescence. Aging cell. 2010, 9(5):667-684.

[6].Kim JH, Choi SH, Lim S, Yoon JW, Kang SM, Kim KW, Lim JY, Cho NH, Jang HC: Sarcopenia and obesity: gender-different relationship with functional limitation in older persons. Journal of Korean medical science. 2013, 28(7):1041-1047.

[7].Tyrovolas S, Koyanagi A, Olaya B, Ayuso‐Mateos JL, Miret M, Chatterji S, Tobiasz‐Adamczyk B, Koskinen S, Leonardi M, Haro JM: Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: a multi‐continent study. Journal of cachexia, sarcopenia and muscle. 2016, 7(3):312-321.

[8].Scheen A: Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion? Diabetes & metabolism. 2005, 31:5S27-25S34.

[9].Williams I, Wheatcroft S, Shah A, Kearney M: Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. International journal of obesity. 2002, 26(6):754-764.

[10].Shichiri M, Ishimaru S, Ota T, Nishikawa T, Isogai T, Hirata Y: Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nature medicine. 2003, 9(9):1166-1172.

[11].Bahram ME, Afroundeh R, Pourvaghar MJ, Seify Skishahr F, Katebi L, Isik O: The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men. IJDO 2023, 15(3):129-138.

[12].Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M: Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults. Aging (Albany NY) 2020, 12(2):1201.

[13].Watanabe T, Nishio K, Kanome T, Matsuyama T-a, Koba S, Sakai T, Sato K, Hongo S, Nose K, Ota H: Impact of salusin-α and-β on human macrophage foam cell formation and coronary atherosclerosis. Circulation. 2008, 117(5):638-648.

[14].Paahoo A, Tadibi V, Behpoor N: Effect of two chronic exercise protocols on pre-atherosclerotic and anti-atherosclerotic biomarkers levels in obese and overweight children. Iranian journal of pediatrics. 2020, 30(2).

[15].Radom-Aizik S, Leu S-Y, Cooper DM, Zaldivar Jr F: Serum from exercising humans suppresses t-cell cytokine production. Cytokine. 2007, 40(2):75-81.

[16.]Watanabe T, Suguro T, Sato K, Koyama T, Nagashima M, Kodate S, Hirano T, Adachi M, Shichiri M, Miyazaki A: Serum salusin-α levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients. Hypertension Research. 2008, 31(3):463-468.

[17].Zhu X, Zhou Y, Cai W, Sun H, Qiu L: Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway. Biochemical and biophysical research communications. 2017, 491(2):515-521.

[18].Russomando L, Bono V, Mancini A, Terracciano A, Cozzolino F, Imperlini E, Orrù S, Alfieri A, Buono P: The effects of short-term high-intensity interval training and moderate intensity continuous training on body fat percentage, abdominal circumference, BMI and vo2max in overweight subjects. Journal of Functional Morphology and Kinesiology. 2020, 5(2):41.

[19].Nazari M, Minasian V, Hovsepian S: The Relationship between Serum Levels of Alpha and Beta Salusins and Lipid Profile, Insulin Resistance, Cardio-Respiratory Fitness and the Effect of Interval Training with Different Intensities in Overweight/Obese Women. Journal of Sport Biosciences. 2021, 13(1):91-107.

[20].Grzegorzewska AE, Niepolski L, Sikora J, Janków M, Jagodzinski PP, Sowinska A: Effect of lifestyle changes and atorvastatin administration on dyslipidemia in hemodialysis patients: a prospective study. Pol Arch Med Wewn. 2014, 124(9):443-451.

[21].Chandra A, Mahdi AA, Ahmad S, Singh RK: Indian herbs result in hypoglycemic responses in streptozotocin-induced diabetic rats. Nutrition research. 2007, 27(3):161-168.

[22].Malayeri SR, Abdolhay S, Behdari R, Hoseini M: The combined effect of resveratrol supplement and endurance training on IL-10 and TNF-α in type 2 diabetic rats. Razi Journal of Medical Sciences. 2019, 25(12):140-149.

[23].Lee O-H, Lee B-Y, Lee J, Lee H-B, Son J-Y, Park C-S, Shetty K, Kim Y-C: Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. Bioresource technology. 2009, 100(23):6107-6113.

[24].Karabag-Coban F, Hazman O, Bozkurt M, Ince S: Antioxidant status and anti-inflammatory effects of oleuropein in streptozotocin-induced diabetic nephropathy in rats. European Journal of Medicinal Plants. 2017, 18(2):1-10.

[25].Elmarakby AA, Sullivan JC: Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovascular therapeutics. 2012, 30(1):49-59.

[26].Kwak JS, Kim JY, Paek JE, Lee YJ, Kim H-R, Park D-S, Kwon O: Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials. Nutrition research and practice. 2014, 8(6):644-654.

[27].Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, Horton ES, Castorino K, Tate DF: Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes care. 2016, 39(11):2065.

[28].Yamaoka-Tojo M, Tojo T, Wakaume K, Kameda R, Nemoto S, Takahira N, Masuda T, Izumi T: Circulating interleukin-18: a specific biomarker for atherosclerosis-prone patients with metabolic syndrome. Nutrition & metabolism. 2011, 8(1):1-8.

[29].Peake J, Della Gatta P, Suzuki K, Nieman D: Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exercise immunology review. 2015, 21:8-25.

[30].Sepehrirad M, Valipour Dehnou V, Fathi M: Effects of hict on serum lipids and glucose levels in elderly women. Iran Journal of Nursing.2018, 31(115):20-28.

[31].Nazari M, Minasian V, Hovsepian S: Effects of two types of moderate-and high-intensity interval training on serum salusin-α and salusin-β levels and lipid profile in women with overweight/obesity. Diabetes, Metabolic Syndrome and Obesity. 2020:1385-1390.

[32].Sun Q, Cornelis MC, Manson JE, Hu FB: Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the US. Diabetes. 2013, 62(1):49-55.

[33].Klika B, Jordan C: High-intensity circuit training using body weight: Maximum results with minimal investment. ACSM's Health & Fitness Journal. 2013, 17(3):8-13.

[34].Afroundeh R: The effect of resistance training with body weight (TRX) on serum levels of Perpetin, Adropine and metabolic factors associated with metabolic syndrome in overweight elderly men. Feyz Medical Sciences Journal. 2022, 26(3):292-301.

[35].Haidari F, Shayesteh F, Mohammad-Shahi M, Jalali M-T, Ahmadi-Angali K: Olive leaf extract supplementation combined with calorie-restricted diet on reducing body weight and fat mass in obese women: result of a randomized control trial. Clinical Nutrition Research. 2021, 10(4):314.

[36].Ahmadizad S, Haghighi AH, Hamedinia MR: Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European journal of Endocrinology. 2007, 157(5):625-632.

37.Nazari M, Minasian V, Hovsepian S: Effects of Two Types of Moderate- and High-Intensity Interval Training on Serum Salusin-α and Salusin-β Levels and Lipid Profile in Women with Overweight/Obesity. Diabetes, metabolic syndrome and obesity : targets and therapy. 2020, 13:1385-1390.

[38].Nikseresht H, Tadibi V, Behpoor N: The Effects of 8 Weeks of Aerobic and Resistance Exercises on Salusins Levels and Inflammatory Indices in Type 2 Diabetic Women. Sport Physiology. 2020, 12(47):73-92.

[39].Jamali S, Omidi M, Yousefi M: Comparison of the effect of resistance versus aerobic exercise on the serum levels of salusin-α and salusin-β, lipid profile and insulin resistance in overweight/obese women. Science & Sports. 2023, 38(5-6):543-550.

[40].Bahram ME, Afroundeh R, Pourvaghar MJ, Seify Skishahr F, Katebi L, Isik O: The Effect of Combined Exercises and Consumption of Mulberry Leaf Extract on Serum Inflammatory Markers Level in Elderly Type 2 Diabetes Mellitus Men. Iranian journal of diabetes and obesity. 2023, 15(3):129-138.

[41].Kunitomo M, Yamaguchi Y, Kagota S, Otsubo K: Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome. Journal of pharmacological sciences. 2008, 107(2):128-137.

[42].Olukman M, Sezer ED, Ülker S, Sözmen EY, Çınar GM: Fenofibrate treatment enhances antioxidant status and attenuates endothelial dysfunction in streptozotocin‐induced diabetic rats. Journal of Diabetes Research. 2010, 2010(1):828531.

[43].Burja B, Kuret T, Janko T, Topalović D, Živković L, Mrak-Poljšak K, Spremo-Potparević B, Žigon P, Distler O, Čučnik S et al: Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells. Frontiers in cardiovascular medicine. 2019, 6:56.

[44].Razmpoosh E, Abdollahi S, Mousavirad M, Clark CCT, Soltani S: The effects of olive leaf extract on cardiovascular risk factors in the general adult population: a systematic review and meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome. 2022, 14(1):151.

[45].Saberi M, Kazemisaleh D, Bolurian V: Effect of Olive Leaf on Mild to Moderate Hypertension Resistant to Normal Treatments. Journal of Medicinal Plants. 2008, 7(27):52-59.

[46].González-Hedström D, García-Villalón Á L, Amor S, de la Fuente-Fernández M, Almodóvar P, Prodanov M, Priego T, Martín AI, Inarejos-García AM, Granado M: Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats. Sci Rep 2021, 11(1):8188.

[47].Richter-Stretton GL, Fenning AS, Vella RK: Skeletal muscle–A bystander or influencer of metabolic syndrome? Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020, 14(5):867-875.

[48].Yu X-H, Fu Y-C, Zhang D-W, Yin K, Tang C-K: Foam cells in atherosclerosis. Clinica chimica acta. 2013, 424:245-252.

[49].Esmaieli M, Abedi B, Fathollahi Shoorabeh F: Effect of aerobic training with Chlorella supplement on insulin resistance and serum ghrelin levels in obese women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018, 21(10):48-56.

[50].Fealy CE, Nieuwoudt S, Foucher JA, Scelsi AR, Malin SK, Pagadala M, Cruz LA, Li M, Rocco M, Burguera B: Functional high‐intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes. Experimental physiology. 2018, 103(7):985-994.

[51].De Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WS: Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PloS one. 2013, 8(3):e57622.

[52].Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar Z: Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. Journal of medicinal food. 2012, 15(7):605-610.

[53].Roriz AKC, Passos LCS, de Oliveira CC, Eickemberg M, Moreira PdA, Sampaio LR: Evaluation of the accuracy of anthropometric clinical indicators of visceral fat in adults and elderly. PloS one. 2014, 9(7):e103499.

[54].Araki R, Fujie K, Yuine N, Watabe Y, Nakata Y, Suzuki H, Isoda H, Hashimoto K: Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial. Nutrition Research. 2019, 67:60-66.

[55].Cox JH, Cortright RN, Dohm GL, Houmard JA: Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity. Journal of Applied Physiology. 1999, 86(6):2019-2025.

[56].Hovanec N, Sawant A, Overend TJ, Petrella RJ, Vandervoort AA: Resistance training and older adults with type 2 diabetes mellitus: strength of the evidence. Journal of aging research. 2012, 2012.

[57].DeFronzo R, Jacot E, Jequier E, Maeder E, Wahren J, Felber J: The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981, 30(12):1000-1007.

[58].Ruderman N: Handbook of exercise in diabetes: American Diabetes Association; 2002.

[59].Siersbæk R, Nielsen R, Mandrup S: Transcriptional networks and chromatin remodeling controlling adipogenesis. Trends in Endocrinology & Metabolism. 2012, 23(2):56-64.

[60].Bouter KE, van Raalte DH, Groen AK, Nieuwdorp M: Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology. 2017, 152(7):1671-1678.

[61].Kishali NF: Serum leptin level in healthy sedentary young men after a short-term exercise. African Journal of Pharmacy and Pharmacology. 2011, 5(4):522-526.

[62].Tond SB, Fallah S, Salemi Z, Seifi M: Influence of mulberry leaf extract on serum adiponectin, visfatin and lipid profile levels in type 2 diabetic rats. Brazilian Archives of Biology and Technology. 2016, 59.