سامانه پشتیبانی خدمات اطلاعات

  اخبار و اعلانات

 آمار

تعداد نشریات163
تعداد شماره‌ها6,762
تعداد مقالات72,827
تعداد مشاهده مقاله131,651,772
تعداد دریافت فایل اصل مقاله103,425,146
Bakhshandeh Seraji, Mehdi, Ghaffari Khaligh, Sahar, Ahmadi-hamedani, Mahmood. (1404). Histopathological investigation of the anti-inflammatory effects of metformin in an experimental model of chronic non-bacterial prostatitis in rats.. , (), -. doi: 10.22059/ijvm.2025.388644.1005723
Mehdi Bakhshandeh Seraji; Sahar Ghaffari Khaligh; Mahmood Ahmadi-hamedani. "Histopathological investigation of the anti-inflammatory effects of metformin in an experimental model of chronic non-bacterial prostatitis in rats.". , , , 1404, -. doi: 10.22059/ijvm.2025.388644.1005723
Bakhshandeh Seraji, Mehdi, Ghaffari Khaligh, Sahar, Ahmadi-hamedani, Mahmood. (1404). 'Histopathological investigation of the anti-inflammatory effects of metformin in an experimental model of chronic non-bacterial prostatitis in rats.', , (), pp. -. doi: 10.22059/ijvm.2025.388644.1005723
Bakhshandeh Seraji, Mehdi, Ghaffari Khaligh, Sahar, Ahmadi-hamedani, Mahmood. Histopathological investigation of the anti-inflammatory effects of metformin in an experimental model of chronic non-bacterial prostatitis in rats.. , 1404; (): -. doi: 10.22059/ijvm.2025.388644.1005723

Histopathological investigation of the anti-inflammatory effects of metformin in an experimental model of chronic non-bacterial prostatitis in rats.

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 اردیبهشت 1404
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2025.388644.1005723
نویسندگان
Mehdi Bakhshandeh Seraji1؛ Sahar Ghaffari Khaligh* 2؛ Mahmood Ahmadi-hamedani3
1Student Research Committee, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
2Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
3Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
چکیده
Background: Chronic prostatitis is one of the most common diseases of the prostate gland, significantly impacting men's quality of life. Today, Metformin is recognized as a medicine with multiple therapeutic potentials, including enhanced anti-inflammatory and antioxidant activity, antitumor effects, benign prostatic hyperplasia, and more.
Objective: The present study aims to investigate the histopathological effects of metformin on chronic non-bacterial prostatitis (CNP) induced by carrageenan in rats.
Methods: Twenty-four male rats were divided into four groups (n=6): Group I (Sham: pseudo CNP-Untreated), II (Control: CNP-Untreated), III (Cernilton: CNP-Standard Treatment), and IV (MET: CNP-Under Treatment). To induce CNP, 0.1 mm carrageenan (1%) was injected into the prostate of groups II, III, and IV. In contrast, an equal amount of normal saline was injected into Group I. Subsequently, rats in Group IV were treated with MET (100 mg/kg), III with Cernilton (100 mg/kg), and I and II with 0.5 ml normal saline, orally daily for up to 3 weeks (21 days). After 21 days, the rats were euthanized, and prostate tissue sections were prepared for histological staining with hematoxylin-eosin.
Results: Group IV had a significant difference in inflammation compared to Group II (P < 0.05). Additionally, from a histopathological perspective, Group IV exhibited a significant reduction in inflammation but in hyperplasia of acinar epithelial cells and hyperemia although there is no significant changes between all groups but reduction of hyperplasia and increase the hyperemia were considerable in Group IV, with the tissue appearance closely resembling that of normal prostate tissue.
Conclusion: In the present study, it has been demonstrated for the first time that Metformin reduces tissue inflammation and its associated complications in the prostate.
کلیدواژه‌ها
Chronic Prostatitis؛ Hyperemia؛ Hyperplasia؛ inflammation؛ Metformin
آمار
تعداد مشاهده مقاله: 24





سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب