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Impact of Nano-chitosan alcoholic basil seed extract on albino diabetic rats | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 08 بهمن 1403 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2025.380269.1005617 | ||
| نویسندگان | ||
| Israa Tareq Al khazaali* ؛ Saadia Saleh Zeiny | ||
| Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Kufa, Iraq. | ||
| چکیده | ||
| Basil seeds are traditionally used for various therapeutic purposes, such as improving digestion, regulating blood sugar, aiding weight loss, cooling the body, relieving stress, lowering blood pressure and cholesterol, improving vision, and reducing inflammation. Recent studies show that Ocimum basilicum extracts have hypoglycemic and hypolipidemic effects in rats. Due to diabetes' significant impact on cardiovascular health, researchers are exploring natural treatments, including plant-based remedies. Nanomaterials are emerging as a promising method for effectively delivering these herbal treatments. Objectives: The aims: to investigate the effect of Nano particle's chitosan of basil seed alcohol extract on albino diabetic mellitus type 1 rats Methods: Basil seed alcoholic extract nanoparticles were examined using FT-IR, X-RD, and FE-SEM. Forty-two adult male rats were divided into six groups: one negative control, one positive control (diabetes induced with alloxan at 100 mg/kg), and four treatment groups. The treatments were empagliflozin (25 mg/kg), nano-chitosan (250 mg/kg), basil seed alcohol extract (250 mg/kg), and nanoparticle basil seed extract (250 mg/kg), administered orally for 21 days. Blood samples were collected to evaluate sugar levels, IL-1β, TNFα, and insulin. Results: The study investigated the effects of nano-chitosan and basil extract in diabetic rats. Diabetes was induced in five groups of rats, leading to increased blood glucose levels. Key findings include elevated insulin levels in all treated groups except the positive control, with the nano-chitosan basil seed extract group showing the most significant improvement. Interleukin-1β levels decreased in all treated groups, with significant reductions observed in groups 5 and 6. Similarly, Tumor Necrosis Factor (TNFα) levels decreased in all treated groups, with the nano-chitosan basil seed extract group showing the most significant reduction compared to groups 3, 4, and 5. Overall, the nano-chitosan basil seed extract demonstrated substantial positive effects on insulin, IL-1β, and TNFα levels in diabetic rats. Conclusions: The use of basil seed extract combined with nano-chitosan has shown a positive impact on increasing insulin levels, reducing blood sugar, and decreasing interleukin1b and tnf levels, which are associated with inflammation and chronic diseases. | ||
| کلیدواژه‌ها | ||
| Hypoglycemic Effects؛ Inflammation Reduction؛ Nanoparticles؛ Diabetic Mellitus Type 1؛ Herbal Remedies | ||
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آمار تعداد مشاهده مقاله: 30 |
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