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Zangene, Somaye, Morovvati, Hassan, Anbara, Hojat, Bernabò, Nicola. (1403). Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice. , (), -. doi: 10.22059/ijvm.2024.373398.1005532
Somaye Zangene; Hassan Morovvati; Hojat Anbara; Nicola Bernabò. "Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice". , , , 1403, -. doi: 10.22059/ijvm.2024.373398.1005532
Zangene, Somaye, Morovvati, Hassan, Anbara, Hojat, Bernabò, Nicola. (1403). 'Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice', , (), pp. -. doi: 10.22059/ijvm.2024.373398.1005532
Zangene, Somaye, Morovvati, Hassan, Anbara, Hojat, Bernabò, Nicola. Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice. , 1403; (): -. doi: 10.22059/ijvm.2024.373398.1005532

Assessment of the Toxicity of Polystyrene Microplastic in the Colon and Liver of Adult NMRI Mice

Iranian Journal of Veterinary Medicine
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 اردیبهشت 1403    اصل مقاله (996.44 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22059/ijvm.2024.373398.1005532
نویسندگان
Somaye Zangene1؛ Hassan Morovvati* 1؛ Hojat Anbara1؛ Nicola Bernabò2
1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
2Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo ,Teramo,Italy
چکیده
Background: Microplastics (MPs), which are emerging environmental contaminants measuring approximately less than 5mm in diameter, have garnered significant attention in recent years. Nevertheless, there is still a scarcity of data concerning the hazards posed by MPs to animals, particularly larger mammals.

Objectives: This study examined polystyrene microplastics (PS-MPs) impact on colon and liver tissue to detect potential inflammation.

Methods: During this experiment, we subjected male mice to a concentration of 2 μm of PS-MPs for six weeks. Adult male mice were randomly assigned to four groups of nine mice each. PS-MPs was administered to three groups of mice at a dose of 0.001, 0.01and 1 mg/kg per day by gevage.

Result: The findings indicated that PS-MPs were detected in the gastrointestinal tracts of mice, leading to an impairment of the intestinal tissue structure. Inflammatory factors increased. Furthermore, the increase of β-catenin and HIF-1α mRNA expression was observed in the groups treated with PS-MPs. PS-MPs also caused several disorders in the tissue structure of the liver, which interfere with the digestive process by affecting the production of bile acids.

Conclusions: This study presented additional data on the toxicity of PS-MPs in a land-dwelling creature, with the purpose of assisting in the evaluation of the health hazards posed by PS-MPs to animals.
کلیدواژه‌ها
Colon؛ Liver؛ Microplastic؛ Inflammation؛ Polystyrene
آمار
تعداد مشاهده مقاله: 145
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