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Protective Effects of Ghrelin Following Experimentally Induced Ischemia-Reperfusion in the Rat Ovary | ||
| Iranian Journal of Veterinary Medicine | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 اسفند 1402 اصل مقاله (1.22 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2024.370891.1005503 | ||
| نویسندگان | ||
| Mahyar Nazari1؛ Arash Kheradmand* 2؛ Masoud Alirezaei3؛ Abbass Raisi2 | ||
| 1Graduated from the Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. | ||
| 2Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. | ||
| 3Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. | ||
| چکیده | ||
| Bachground: Ovarian torsion, a critical gynecological emergency, leads to blockage of the ovarian artery and vein, ultimately causing ischemia in the ovary. Objective: This study aims to investigate the potential antioxidative effects of ghrelin in the context of ischemia-reperfusion injury in the rat ovary. Methods: Twenty-one female adult Wistar rats were assigned to three groups (n = 7/group): Group 1, sham-operated; Group 2 as ischemia-saline, by which 100 µl Saline was administered intraperitoneally 30 min prior to the 2-hr of ischemia and simultaneously with the beginning of 2-hr reperfusion; and Group 3, as ischemia-ghrelin, by which 10 nmol ghrelin was administered intraperitoneally 30 min prior to the 2-hr of ischemia and simultaneously with the beginning of 2-hr reperfusion. The right ovaries excised in each group underwent biochemical analysis. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant score (TAS), and catalase (CAT) were assessed as biochemical parameters. Result: There were no significant differences among groups in SOD, GPx activities (P>0.05). MDA level was higher in the ischemia-saline group compared to the control group and was lower in the ischemia-ghrelin group compared to the ischemia-saline group, significantly (P<0.05). CAT and TAS activities were significantly decreased in the saline group compared to the sham-operated group and increased significantly in the ghrelin-treated group compared to the saline group (P<0.05). Conclusions: This investigation provides novel evidence of the antioxidant properties of ghrelin in rat ovary ischemia-reperfusion injury. | ||
| کلیدواژه‌ها | ||
| ghrelin؛ ischemia-reperfusion؛ rat ovary؛ torsion؛ torsion/detorsion | ||
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آمار تعداد مشاهده مقاله: 108 تعداد دریافت فایل اصل مقاله: 226 |
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