The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer

Heydari, Shahin; Irandoust, Khadijeh; Taheri, Morteza

doi:10.22059/sshr.2023.357150.1081

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	The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer
Sport Sciences and Health Research
مقاله 2، دوره 15، شماره 1، فروردین 2023، صفحه 13-22 اصل مقاله (712.34 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22059/sshr.2023.357150.1081
نویسندگان
Shahin Heydari¹؛ Khadijeh Irandoust^* ¹؛ Morteza Taheri²
¹Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran.
²Department of Behavioural and Cognitive Sciences in Sport, Faculty of Sport Science and Health, University of Tehran, Tehran, Iran.
چکیده
Background: Expression of mucosal levels would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine. Aim: The purpose of this sudy was to investigate the effect of 8 weeks of quercetin supplementation and intermittent exercise on protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in rats with colon cancer. Material and Methods: Tewenty-four rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin + exercise (n=6) and control group (n=6). Colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 8 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. Exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-min rest in 8 weeks. ANOVA was used to analyze data. The level of significance was set at P<0.05. Results: It was suggested that there was a significant difference in protein levels of intestinal Muc5Ac, Muc4 and polyphosphate in all groups (P<0.05). Furthermore, it was also indicated that Muc5Ac levels was significantly higher in the quercetin+ exercise group other than pther groups (P<0.05). Conclusions: It was concluded that intermittent exercise and quercetin supplementation would increase the levels of Muc5Ac and Muc4 proteins in the large intestine of mice with colon cancer.
کلیدواژه‌ها
intermittent exercise؛ Muc4؛ Muc5Ac؛ polyphosphate؛ quercetin supplement

مراجع
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آمار

The effect of 8 weeks of quercetin supplementation and intermittent exercise on gene expression of Muc5Ac, Muc4 and polyphosphate in rats with colon cancer

[1] Shirvani H, Bazgir B, Rahimi M, Isanejad A, Samadi M, Sobhani V, et al. "Interval exercise training affects expression of MCT-1, GLUT-1, PFK-1 and p53 as key metabolic regulators on azoxymethane-induced experimental colon cancer". 2021. https://doi.org/10.21203/rs.3.rs-151527/v1.

[2] Terzić J, Grivennikov S, Karin E, Karin M. "Inflammation and colon cancer". Gastroenterology. 2010; 138(6): 2101-14. e5. https://doi.org/10.1053/j.gastro.2010.01.058.

[3] Arani SH, Kerachian MA. "Rising rates of colorectal cancer among younger Iranians: is diet to blame?". Current Oncology. 2017; 24(2): e131. https://doi.org/10.3747/co.24.3226

[4] Hofseth LJ, Ying L. "Identifying and defusing weapons of mass inflammation in carcinogenesis". Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2006; 1765(1): 74-84. https://doi.org/10.1016/j.bbcan.2005.08.005.

[5] Itzkowitz SH, Bloom EJ, Kokal WA, Modin G, Hakomori SI, Kim YS. "Sialosyl‐Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients". Cancer. 1990; 66(9): 1960-6. https://doi.org/10.1002/1097-0142(19901101)66:9<1960::AID-CNCR2820660919>3.0.CO;2-X

[6] Forgue‐Lafitte ME, Fabiani B, Levy PP, Maurin N, Fléjou JF, Bara J. "Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer". International Journal of Cancer. 2007; 121(7): 1543-9. https://doi.org/10.1002/ijc.22865

[7] Pothuraju R, Pai P, Chaudhary S, Siddiqui JA, Cox JL, Kaur S, et al. "Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer". Aging (Albany NY). 2022; 14(5): 2025. https://doi.org/10.18632/aging.203935.

[8] Moghadamyeghaneh Z, Hanna MH, Hwang G, Mills S, Pigazzi A, Stamos MJ, et al. "Outcomes of colon resection in patients with metastatic colon cancer". The American Journal of Surgery. 2016; 212(2): 264-71. https://doi.org/10.1016/j.amjsurg.2016.01.025

[9] Müller WE, Schröder HC, Neufurth M, Wang X. "An unexpected biomaterial against SARS-CoV-2: Bio-polyphosphate blocks binding of the viral spike to the cell receptor". Materials Today. 2021; 51: 504-524. https://doi.org/10.1016/j.mattod.2021.07.029

[10] Neufurth M, Wang X, Wang S, Schröder HC, Müller WE. "Caged dexamethasone/quercetin nanoparticles, formed of the morphogenetic active inorganic polyphosphate, are strong inducers of MUC5AC". Marine Drugs. 2021; 19(2): 64. https://doi.org/10.3390/md19020064

[11] Trojian TH, Mody K, Chain P. "Exercise and colon cancer: primary and secondary prevention". Current Sports Medicine Reports. 2007; 6(2): 120-4. https://doi.org/10.1097/01.CSMR.0000306452.02069.fa. https://doi.org/10.1007/BF02941153.

[12] Xu G, Shi H, Ren L, Gou H, Gong D, Gao X, et al. "Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles". International Journal of Nanomedicine. 2015; 10: 2051. https://doi.org/10.2147/IJN.S75550.

[13] Wang W, Sun C, Mao L, Ma P, Liu F, Yang J, Gao Y. "The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review". Trends in Food Science & Technology. 2016; 56: 21-38. https://doi.org/10.1016/j.tifs.2016.07.004.

[14] Damiano S, Sasso A, De Felice B, Di Gregorio I, La Rosa G, Lupoli GA, et al. "Quercetin increases MUC2 and MUC5AC gene expression and secretion in intestinal goblet cell-like LS174T via PLC/PKCα/ERK1-2 pathway". Frontiers in Physiology. 2018; 9: 357. https://doi.org/10.3389/fphys.2018.00357.

[15] Newton RU, Galvao DA. "Exercise in prevention and management of cancer". Current Treatment Options in Oncology. 2008; 9(2): 135-46. https://doi.org/10.1007/s11864-008-0065-1.

[16] Darband SG, Sadighparvar S, Pakdel FG, Naderi S, Majidinia M. "Involvement of IGF/IGFBP/Erk axis in the exercise-mediated preventive effects on colorectal cancer in rats". International Journal of Clinical and Experimental Pathology. 2021; 14(5): 608.

[19] Volstatova T, Marchica A, Hroncova Z, Bernardi R, Doskocil I, Havlik J. "Effects of chlorogenic acid, epicatechin gallate, and quercetin on mucin expression and secretion in the Caco‐2/HT29‐MTX cell model". Food Science & Nutrition. 2019; 7(2): 492-8. https://doi.org/10.1002/fsn3.818.

[20] Barcelo A, Claustre J, Moro F, Chayvialle J, Cuber J, Plaisancié P. "Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon". Gut. 2018; 46(2): 218-24. https://doi.org/10.1136/gut.46.2.218.