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Yazdanian, M., Zihayat, B, Moshafi, MH, Khodadadi, A, Peimani, A, Shamsaddini, A, Nourhashemi, M, Foroumadi, Alireza. (1399). Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives. , 31(2), 147-153. doi: 10.22059/jsciences.2020.283309.1007419
M. Yazdanian; B Zihayat; MH Moshafi; A Khodadadi; A Peimani; A Shamsaddini; M Nourhashemi; Alireza Foroumadi. "Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives". , 31, 2, 1399, 147-153. doi: 10.22059/jsciences.2020.283309.1007419
Yazdanian, M., Zihayat, B, Moshafi, MH, Khodadadi, A, Peimani, A, Shamsaddini, A, Nourhashemi, M, Foroumadi, Alireza. (1399). 'Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives', , 31(2), pp. 147-153. doi: 10.22059/jsciences.2020.283309.1007419
Yazdanian, M., Zihayat, B, Moshafi, MH, Khodadadi, A, Peimani, A, Shamsaddini, A, Nourhashemi, M, Foroumadi, Alireza. Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives. , 1399; 31(2): 147-153. doi: 10.22059/jsciences.2020.283309.1007419

Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives

Journal of Sciences, Islamic Republic of Iran
مقاله 6، دوره 31، شماره 2، تیر 2020، صفحه 147-153    اصل مقاله (270.35 K)
نوع مقاله: Original Paper
شناسه دیجیتال (DOI): 10.22059/jsciences.2020.283309.1007419
نویسندگان
M. Yazdanian1؛ B Zihayat1؛ MH Moshafi1؛ A Khodadadi1؛ A Peimani1؛ A Shamsaddini1؛ M Nourhashemi2؛ Alireza Foroumadi* 2
1Kerman University of Medical Sciences
2Tehran University of Medical Sciences
چکیده
A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial effects against the Gram-positive bacteria. The oxidation of synthesized compounds to sulfinyl and sulfonyl bearing analogues did not improve the activity.
کلیدواژه‌ها
1,3,4-Thiadiazole؛ Antibacterial activity؛ Synthesis
مراجع
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