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بررسی اثر عصاره هیدروالکلی گیاه اسطوخدوس (Lavandula officinalis) براعمال حرکتی در موش صحرایی نر مدل شبه بیماری پارکینسون | ||
| مجله تحقیقات دامپزشکی (Journal of Veterinary Research) | ||
| مقاله 12، دوره 72، شماره 2، تیر 1396، صفحه 235-242 اصل مقاله (1.11 M) | ||
| شناسه دیجیتال (DOI): 10.22059/jvr.2017.62667 | ||
| نویسندگان | ||
| مریم ابریشم دار* 1؛ احمدعلی معاضدی1؛ اردشیر ارضی2؛ غلامعلی پرهام3 | ||
| 1گروه زیست شناسی، دانشکده علوم پایه دانشگاه شهید چمران، اهواز | ||
| 2گروه فارماکولوژی، دانشکده داروسازی دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران | ||
| 3گروه آمار، دانشکده ریاضی دانشگاه شهید چمران، اهواز، ایران | ||
| چکیده | ||
| زمینه مطالعه: بیماری پارکینسون یک اختلال ناشی از تخریب عصبی است که در حدود 1% از جمعیت بالای 50 سال اثر می‌گذارد. به طور کلاسیک پارکینسون به عنوان یک بیماری مربوط به سیستم حرکتی در نظر گرفته می‌شود و تشخیص آن بر مبنای گروهی از علائم حرکتی نظیر سفتی عضلات، کندی حرکت و اختلال در رفلکس‌های حرکتی و وضعی بنا نهاده می‌شود. هدف: هدف از این مطالعه ارزیابی اثرات عصاره هیدروالکلی گیاه اسطوخدوس بر اختلالات حرکتی موش‌های صحرایی مدل شبه بیماری پارکینسون است. روش کار: موش‌های صحرایی نر نژاد ویستار به چهار گروه تقسیم شدند (7=n). علائم بیماری پارکینسون قبل از تجویز عصاره اسطوخدوس به وسیله تزریق درون صفاقی (ip) رزرپین (mg/kg 5 ) ایجاد شد. سه گروه از موش‌های صحرایی مقادیر مختلف عصاره اسطوخدوس (mg/kg, po 400، 300، 200 ) و گروه شاهد نیز به مدت 6 روز و روزی دوبار به همان حجم آب مقطر دریافت کردند. در روز هفتم، سختی عضلات و دیگر علائم پارکینسون به وسیله بار تست، روتارود و میدان باز اندازه گرفته شد. نتایج: در این مطالعه بهبود علائم ناشی از بیماری پارکینسون با استفاده از عصاره هیدروالکلی اسطوخدوس مشاهده نشد و اختلالات حرکتی آن‌ها در مقایسه با گروه شاهد کاهش نیافت. نتیجه گیری نهایی: عصاره هیدروالکلی اسطوخدوس بر اختلالات حرکتی ناشی از بیماری پارکینسون بی تأثیر است. | ||
| کلیدواژه‌ها | ||
| پارکینسون؛ اسطوخدوس؛ بارتست؛ روتارود؛ جعبه باز | ||
| عنوان مقاله [English] | ||
| Hydroalcoholic extract effect of Lavandula officinalis on motor functions in the male rat model of pseudo Parkinson’s disease | ||
| نویسندگان [English] | ||
| Maryam Abrishamdar1؛ Ahmad Ali Moazedi1؛ Ardeshir Arzi2؛ Gholam Ali Parham3 | ||
| 1Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, Ahvaz, Iran | ||
| 2Department of Pharmacology, Faculty of Pharmacology, Jondi Shapour University, Ahvaz, Ahvaz, Iran | ||
| 3Department of Statistics, Faculty of Mathematics, ShahidChamran University, Ahvaz, Iran | ||
| چکیده [English] | ||
| BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder that involves approximately 1% of the population older than 50 years. Classically, PD is considered a motor system disease, and its diagnosis is based on the presence of a set of cardinal motoric signs (e.g. rigidity, bradykinesia, motor and postural reflex disturbance). ObjectiveS: The present study aimed to evaluate the effects of hydro-alcoholic extract of lavender (Lavandula officinalis) on motor disorders of pseudo PD rats. Methods: Male Wistar rats were divided into four groups (n=7). PD signs were induced by intra-peritoneal (IP) injection of reserpine (5mg/kg) prior to administration of the lavender extract. Three goups of rats received different doses (200, 300, 400 mg/kg, P.O) of the lavender extract and sham group received distilled water at the same volume for six days and two times per day. At the seventh day, Catalepsy and other signs of PD were measured in the bar test, rotarod and open field. Results: In this study, improvement in signs of Parkinson disease were not observed by applying lavender hydro-alcoholic extract and motor disorders were not reduced in comparison with sham group. Conclusions: The lavender hydro-alcoholic extract does not have any effect on motor disorders of Parkinson disease. | ||
| کلیدواژه‌ها [English] | ||
| Parkinson, Lavandula officinalis, rotarod, bar test, open field | ||
| مراجع | ||
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