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Bhuvaneshwari, R., Babu Rajendran, R., Kumar, K.. (1391). Induction of DNA Damage and GADD45β gene Mutation in Zebra fish (Danio rerio) due to Environmentally Relevant Concentrations of Organochlorine Pesticides & Heavy Metals. , 7(1), 219-224. doi: 10.22059/ijer.2012.600
R. Bhuvaneshwari; R. Babu Rajendran; K. Kumar. "Induction of DNA Damage and GADD45β gene Mutation in Zebra fish (Danio rerio) due to Environmentally Relevant Concentrations of Organochlorine Pesticides & Heavy Metals". , 7, 1, 1391, 219-224. doi: 10.22059/ijer.2012.600
Bhuvaneshwari, R., Babu Rajendran, R., Kumar, K.. (1391). 'Induction of DNA Damage and GADD45β gene Mutation in Zebra fish (Danio rerio) due to Environmentally Relevant Concentrations of Organochlorine Pesticides & Heavy Metals', , 7(1), pp. 219-224. doi: 10.22059/ijer.2012.600
Bhuvaneshwari, R., Babu Rajendran, R., Kumar, K.. Induction of DNA Damage and GADD45β gene Mutation in Zebra fish (Danio rerio) due to Environmentally Relevant Concentrations of Organochlorine Pesticides & Heavy Metals. , 1391; 7(1): 219-224. doi: 10.22059/ijer.2012.600

Induction of DNA Damage and GADD45β gene Mutation in Zebra fish (Danio rerio) due to Environmentally Relevant Concentrations of Organochlorine Pesticides & Heavy Metals

International Journal of Environmental Research
مقاله 21، دوره 7، شماره 1، فروردین 2013، صفحه 219-224    اصل مقاله (489.1 K)
نوع مقاله: Original Research Paper
شناسه دیجیتال (DOI): 10.22059/ijer.2012.600
نویسندگان
R. Bhuvaneshwari* ؛ R. Babu Rajendran؛ K. Kumar
Department of Environmental Biotechnology, School of Environmental Sciences, Bharathidasan University, Tiruchirappalli-24, India
چکیده
Zebra fish were exposed to environmentally relevant concentration of pesticides and metals for
a period of 14 days. The individual and the combined toxicity of pesticides and metals were studied. Damage caused to the DNA and induction of mutation in the GADD45β gene was investigated in this study. The present investigation revealed that exposure of zebra fish to pesticides and metals induced DNA damage and also mutation in the GADD45β gene. The pesticides treated group (III) showed significantly higher damage followed by metals treated group (II). The DNA damage was comparatively less in the pesticides and metals exposed group (IV). GADD45β gene which is considered to be one of the most important gene involved in G phase arrest, has been found to be mutated in zebra fish when exposed to metals and pesticides. The comparison of amplified gene sequence of GADD45β gene with the sequence of the zebra fish retrieved from the NCBI confirmed the mutation in the gene sequence of zebra fish treated with pesticides and metals. The induction of DNA damage in fish due to contaminants may lead to mutations, which contribute towards the multistage carcinogenesis process.
کلیدواژه‌ها
Zebra fish؛ Pesticides؛ Metals؛ DNA damage؛ Gene mutation
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