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Plasma pharmacokinetics and muscle disposition of marbofloxacin in chickens | ||
| Iranian Journal of Veterinary Medicine | ||
| مقاله 1، دوره 10، شماره 1، فروردین 2016، صفحه 1-6 اصل مقاله (918.64 K) | ||
| نوع مقاله: Pharmacology | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2016.57044 | ||
| نویسندگان | ||
| Natalia Urzúa1؛ C. Errecalde1؛ Guillermo Prieto* 1؛ C. Lüders2؛ E. Picco3؛ M. Paula Tonini1 | ||
| 1Department of Pharmacology, Faculty of Agriculture and Veterinary, National University of Río Cuarto, Río Cuarto, Argentina | ||
| 2School of Veterinary Medicine, Catholic University of Temuco, Temuco, Chile | ||
| 3Department of Pharmacology, Faculty of Veterinary Sciences, National University of the Litoral, Esperanza, Argentina | ||
| چکیده | ||
| Background: Reports on the pharmacokinetics of marbofloxacin in birds are scarce, even when it is a useful tool in poultry production. OBJECTIVES: Determining marbofloxacin kinetic parameters in plasma and muscle arrangement after intravenous and oral administrations and establishing its withdrawal period. METHODS: Clinical healthy chickens (1.08±0.22 kg) were used as experimental subjects, formed in groups of 5. In Group A (n= 45) birds received 2 mg/kg of marbofloxacin intravenously while group B (n= 65) was given the same oral dose after fasting for 12 hours. Blood samples in the groups and 5 g of muscle were obtained at different times, in A group up to 24 hours and in B group until 120 hours after application. Once the samples were obtained and treated, marbofloxacin was quantified by HPLC. RESULTS: Marbofloxacin in fasted chickens is almost completely absorbed (F= 97%), mean residence time is moderate (6.9 hours), with a high volume of distribution. Orally, mean residence time is less in plasma (4.9 hours) and the withdrawal time was calculated 2.5 days. CONCLUSIONS: The kinetic results are consistent with those presented by other fluoroquinolones in poultry and are in line with short production cycles in chickens. | ||
| کلیدواژهها | ||
| Chickens؛ HPLC؛ marbofloxacin؛ pharmacokinetics | ||
| مراجع | ||
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