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. (1374). ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE. , 6(4), -.
. "ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE". , 6, 4, 1374, -.
. (1374). 'ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE', , 6(4), pp. -.
. ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE. , 1374; 6(4): -.

ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE

Journal of Sciences, Islamic Republic of Iran
مقاله 7، دوره 6، شماره 4، اسفند 1995    اصل مقاله (270.4 K)
چکیده
The use of accelerated temperature stability studies using the Arrhenius
relationship is routine for estimating the stability of a drug at room temperature.
Therefore, the acceleration method is used to determine the expiration date of
dexamethasone aqueous formulation manufactured in Iran. A high-performance
liquid chromatography (HPLC) method utilizing ultraviolet (UV) detection for
dexamethasone disodium phosphate and ophthalmic solution is described.
Using the kinetic information generated from the high-temperature studies, at
60,70, 80 and 90°C, an Arrhenius plot for dexamethasone disodium phosphate
degradation was constructed and the shelf-life of the drug was estimated
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