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ANALYSIS OF DEXAMETHASONE SODIUM PHOSPHATE INJECTION AND OPHTHALMIC SOLUTION BY HPLC, KINETIC INTERPRETATION AND DETERMINATION OF SHELF LIFE | ||
| Journal of Sciences, Islamic Republic of Iran | ||
| مقاله 7، دوره 6، شماره 4، زمستان 1995 اصل مقاله (270.4 K) | ||
| چکیده | ||
| The use of accelerated temperature stability studies using the Arrhenius relationship is routine for estimating the stability of a drug at room temperature. Therefore, the acceleration method is used to determine the expiration date of dexamethasone aqueous formulation manufactured in Iran. A high-performance liquid chromatography (HPLC) method utilizing ultraviolet (UV) detection for dexamethasone disodium phosphate and ophthalmic solution is described. Using the kinetic information generated from the high-temperature studies, at 60,70, 80 and 90°C, an Arrhenius plot for dexamethasone disodium phosphate degradation was constructed and the shelf-life of the drug was estimated | ||
| عنوان مقاله [English] | ||
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| چکیده [English] | ||
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آمار تعداد مشاهده مقاله: 3,180 تعداد دریافت فایل اصل مقاله: 2,557 |
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