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Shahgholian, Lohrasb, Teshfam, Mosoud, اسدیان, پیمان, Hasanpour, Hosein, نیکبخت بروجنی, غلامرضا. (1391). Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer). , 6(4), 241-247. doi: 10.22059/ijvm.2012.30229
Lohrasb Shahgholian; Mosoud Teshfam; پیمان اسدیان; Hosein Hasanpour; غلامرضا نیکبخت بروجنی. "Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)". , 6, 4, 1391, 241-247. doi: 10.22059/ijvm.2012.30229
Shahgholian, Lohrasb, Teshfam, Mosoud, اسدیان, پیمان, Hasanpour, Hosein, نیکبخت بروجنی, غلامرضا. (1391). 'Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)', , 6(4), pp. 241-247. doi: 10.22059/ijvm.2012.30229
Shahgholian, Lohrasb, Teshfam, Mosoud, اسدیان, پیمان, Hasanpour, Hosein, نیکبخت بروجنی, غلامرضا. Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer). , 1391; 6(4): 241-247. doi: 10.22059/ijvm.2012.30229

Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)

Iranian Journal of Veterinary Medicine
مقاله 10، دوره 6، شماره 4 - شماره پیاپی 1369670، اسفند 2012، صفحه 241-247    اصل مقاله (166.77 K)
شناسه دیجیتال (DOI): 10.22059/ijvm.2012.30229
نویسندگان
Lohrasb Shahgholian1؛ Mosoud Teshfam1؛ پیمان اسدیان2؛ Hosein Hasanpour2؛ غلامرضا نیکبخت بروجنی3
1گروه فیزیولوژی دامپزشکی، دانشکده علوم تخصصی دامپزشکی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات
2گروه علوم درمانگاهی، دانشکده دامپزشکی دانشگاه لرستان
3گروه میکروبیولوژی،دانشکده دامپزشکی دانشگاه تهران
چکیده
Background: Broilers lung mechanisms that regulate endothelin (ET) in the lung are complex and poorly understood. Objectives: Methods: In this experiment lung ET-1 mRNA levels and lung mRNA expression for the ET(A) receptors were determined in lung tissue weekly (term = 42 days, intervals = 7 days). Serum endothelin concentration was also measured at these ages. Results: The study showed that expression of endothelin in lungs of layers and broilers was similar during the first three weeks and the overall trend of ET-1 expression was increasing. However, there was a significant increase of ET-1 expression which started from the fourth week and gradually increased until the end of the commercial life of the chicken (day 42). ET-A expression in the lungs of broilers was significantly higher than layers during the last three weeks of life. Overall, trends of serum ET-1 concentration increased in both layers and broilers, but serum ET-1 concentration in broilers was significantly higher than layers. Conclusions: The higher level of serum Endothelin and expression of ET-1 and ETA in broiler lungs may explain the higher sensitivity of broilers to the vasoconstrictions activity of endothelin and the higher sensitivity of these animals to pulmonary hypertension (PH).
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