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Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas | ||
| Iranian Journal of Veterinary Medicine | ||
| مقاله 6، دوره 6، شماره 1 - شماره پیاپی 848859، خرداد 2012، صفحه 29-32 اصل مقاله (2.03 M) | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2012.24622 | ||
| نویسنده | ||
| Saeed Hesaraki | ||
| گروه آسیب شناسی، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران | ||
| چکیده | ||
| BACKGROUNDS: Seminoma is frequently observed in human and canine testes especially in cryptorchids. Canine and human seminomas are typically associated with leukocytic infiltration. OBJECTIVES: We aimed to identify the type of lymphocytes that infiltrate to seminomas. METHODS: Tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. Routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. RESULTS: Lymphocytes in seminomas were predominantly T cytotoxic (CD3+, CD8+) cells. These cells were distributed diffusely, but patchy around the vessels. B-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. CONCLUSIONS: The results of this study showed that the lymphocyte infiltrating cells are mainly T lymphocytes particularly CD8 cytotoxic type. BACKGROUNDS: Seminoma is frequently observed in human and canine testes especially in cryptorchids. Canine and human seminomas are typically associated with leukocytic infiltration. OBJECTIVES: We aimed to identify the type of lymphocytes that infiltrate to seminomas. METHODS: Tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. Routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. RESULTS: Lymphocytes in seminomas were predominantly T cytotoxic (CD3+, CD8+) cells. These cells were distributed diffusely, but patchy around the vessels. B-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. CONCLUSIONS: The results of this study showed that the lymphocyte infiltrating cells are mainly T lymphocytes particularly CD8 cytotoxic type. | ||
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