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Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat | ||
| Iranian Journal of Veterinary Medicine | ||
| مقاله 7، دوره 5، شماره 3 - شماره پیاپی 714077، آذر 2011، صفحه 173-177 اصل مقاله (163.45 K) | ||
| شناسه دیجیتال (DOI): 10.22059/ijvm.2011.23845 | ||
| نویسندگان | ||
| Morteza Zendehdel3؛ Majid Taati2؛ Arash Kheradmand2؛ Farzam Sheikhzadeh1؛ | ||
| 1گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز | ||
| 2گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد | ||
| 3گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران | ||
| چکیده | ||
| Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometrical properties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa. | ||
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