Desmin expression by a gastrointestinal stromal tumor in a dog

	Desmin expression by a gastrointestinal stromal tumor in a dog
Iranian Journal of Veterinary Medicine
مقاله 6، دوره 4، شماره 4 - شماره پیاپی 391317، بهمن 2010 اصل مقاله (7.12 M)
شناسه دیجیتال (DOI): 10.22059/ijvm.2010.22099
نویسندگان
Saeed Hesaraki؛ Seyed Mahdi Nasiri؛ Ali reza Seraji
چکیده
This report describes the histological and immunohistochemical features of a small intestinal tumor that resembled a human gastrointestinal stromal tumor (GISTs) in a seven-year-old male cross-breed dog. This was unique because of the expression of desmin by the tumor. Grossly, the white-gray tumor measured 8.0 × 4.0 × 6.5 cm and was 760 gram in weight. It was cystic and enveloped the jejunum. Histopathologically, long spindle-shaped cells were arranged densely in the interwoven pattern. The tumor cells had a low rate of mitosis, were pleomorphic, and were positive for vimentin, ?-smooth muscle actin, desmin, S100 and C-KIT and negative for CD34 on immunohistochemistry. The expression of desmin in the cytoplasm of this tumor cells is a rare event in these types of tumors.
کلیدواژه‌ها
C-Kit

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