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. (1369). A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS. , 1(4), -.
. "A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS". , 1, 4, 1369, -.
. (1369). 'A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS', , 1(4), pp. -.
. A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS. , 1369; 1(4): -.

A QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS

Journal of Sciences, Islamic Republic of Iran
مقاله 3، دوره 1، شماره 4، آبان 1990    اصل مقاله (418.84 K)
چکیده
Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular
properties and structure - activity relationships of dihydropyridine (DHP) type
calcium antagonists. There is a good corielation between the net atomic charges on
various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity.
.Also, activity decreases with increasing free rotation of the phenyl ring. These results
indicate that the binding of the 4 - phenyl ring to a rigid part of the receptor plays an
important part in the activity of DHP calcium antagonists
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